RA.pdf

R H E U M AT O I D A RT H R I T I S Rheumatoid arthritis (RA) is autoimmune inflammatory systemic disease characterized by chronic PATHOGENESIS: aseptic synovitis & erosive-destructive joint damage with a progressive course that gradually leads There are 2 major...

R H E U M AT O I D A RT H R I T I S Rheumatoid arthritis (RA) is autoimmune inflammatory systemic disease characterized by chronic PATHOGENESIS: aseptic synovitis & erosive-destructive joint damage with a progressive course that gradually leads There are 2 major subtypes of RA according to the presence or absence of anti-citrullinated to the destruction of articular cartilage & bone. RA can cause visceral organ damage. protein ab (ACPAs). Citrullination is catalyzed by the ca2+-dependent enzyme peptidylarginine-deiminase (PAD), Course of the disease: Typically, polyarthritis, but it may initially be like oligo-arthritis (1h ACR & EULAR 2010 RA classification criteria: Incidence of RF in other diseases ACPA or anti-CCP (antibodies against citrullinated peptide): For diagnosis necessary: 6 points Arthritis Specificity > 90%, sensitivity 56-80% Low (+) if its level is greater than the upper limit of RA 60-80% 50-60% of anti-CCP can be detected within 3-6 months after the onset of symptoms normal (ULN), but less than 3x the ULN, & high (+) Juvenile arthritis 15% The incidence in healthy individuals is