Growth Factors PDF
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This document discusses growth factors, their roles in stimulating cell growth, division, and survival, and how they contribute to wound healing and angiogenesis. It explains the functions of different growth factors and describes the mechanisms involved.
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quicklyreplaced bystemcells sit inGounless stimulated byinjury cannot be regenerated Renal tubulecells arestable eve...
quicklyreplaced bystemcells sit inGounless stimulated byinjury cannot be regenerated Renal tubulecells arestable eventually willregenerate Yform are iii Enraged Libel cells can heal on its own doesnotneedto be removed vesselpermeability to allowscells migrate frombloodstream to damagedtissue 1784418 newvessels bringwoundedges closer together type 3 collagen degraded byproteases fibroblasts laydowntype I collagen toform a more durablestructure receptor Lilliputian Ginesshifterthrequidiff cellgrowth celldivision B cell survival Fibroblasts cellsthatreside inthe extracellular matrix of tissues makethe groundfibers thatcompose theextracellular matrix Growth factors are secreted byactivatedplatelets macrophages to target fibroblasts Dueto enhanced fibroblastproliferation toomuch Pdgf secretion causes to muchfibroblast stimulation which leads to an excess production of collagen at the site of injury Excess collagen withinborders Excess production of scar tissuethatextends of the initial wound beyond the borders of the initial wound Fixed bysurgery 3 isoforms B1 B2 B3 TGF B promotesfibroblastgrowth collagen production TGF B binds cell membraneTGF B receptors whichphosphorylate SMDproteinsthat transducedtheTGFB signal FGF FGFIO bind to FGF receptors 1 4 that have tyrosinekinase activity is themajorangiogenesis substance in thedevelopingembryo stimulates growth ofnewbloodvessels acts on EGFR to stimulate proliferation EGFR is commonly mutated in cancers to cause unstopped cell proliferation need both signal receptor for complete signal
