Complement PDF
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UDEM
Dr. Antonio Muñiz Buenrostro
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Summary
These are notes on the complement system, covering the classical and alternate pathways. The notes include diagrams and details on different components and regulatory mechanisms.
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8. The complement Dr. Antonio Muñiz Buenrostro REMEMBER...
8. The complement Dr. Antonio Muñiz Buenrostro REMEMBER 2 and 24 Leatic way note MBL asociated protect & means one : can sain complet Classical Alternate criquo/con active starts directly MBL antibodiea with 13 Pathway this : manose protein : is MASP whats spontaneous > is gonna this i thin - - activate the pathway Antigen-Antibody ↓ if factor negulated > - complex I is not 22 and (4 -> components = 2 = Cls 1 = (g 2 = (In C3C = autoimmunity MBL with the MASP proteins ① C3b binding ↳ deficiency difference 21 (only pathway that has it > - : complex opsonization endsa , ↓ of this For the complement 2 I factor · CY convertage exYo 23 activates C2 and C4 (see Lectin pathway a proteins to be activated letters ! activateswith spanter they need to be , - has Cl inhibitor another way C3- + hydrolyzed &3 ; < - + ~ Factor B we need it binding engmente - Ci to start the 24bp Factor 1 , MCP DAF CK1 they block 23 convertise hidrolized t ↓ geta : proces we - , , , or ↳ remember ↓ for this important exam the most C3i +B important - has [1 inhibitor protein actu Ba needs 24bp Factor ↓ ↳ - , 1 , MCP, DAF and (RT : blocks the (3i + Bb -> different 23 convertise it activat 2za tion) 1 convertas deficiency D inhibito angidema 23 convertase 23 - of can also blocked be I ↓ ↓ by Factor Cy activates Cyb binds inflamatory * convertase /1 to 25 to C5 convertase get -> Czb combe ↓ ↓ blockedefactori binds with to activate Factor blocks -4 1 : C3b convertise · CJ ↳ remember fr exam and activates · has Factor H a CD55 and it C5b CD35 ↓ ↓ ↓ activates (J gonnaas blocks MAC the zzconvertage and we get mac complex CTb(9 c5bC9 inhibite to Farmers Instead of using (2and 24 this ↑ un - · wer feeta wer feature inhibited circulatingeus ~nation ↑ CD59 and Vitronectin and these two eye 22 and C4 !!! Clusterin adding itself to the complex ↓ defcim to lead can more inflamation not is if C3a. blocked