Testicular Lesions PDF

Testicular Lesions Anomalies - Congenital ↓ Cryptorchidism...

Testicular Lesions Anomalies - Congenital ↓ Cryptorchidism S & - Tumors J - > - Def : complete/partial failure Vascular Lesions of of testes to descend Disorders - Pathogenesis : Tunica Vaginalis ↓ Testes small firm. 1. Cryptorchidism- Risk of germ cell Tumors + X3 5 - , bes > - N/E : are , Torsion of high temp of undescended testes.. 2 genetics - familial of spermatic cord lesion > M/E - : 1. Testicular atrophy - Def : twisting character 3 of testis. Carcinogens - Drugs Radiation endocrine , , abn.. Sertoli cells 2 - cutoff venous drainage - blood in Tunica Vaginalis. thick 3 BM - Types : Hematocele - follows testicular trauma/ torsion 4 ↑ classification. Leydig cells · Neonatal : wo associated anatomic defect. - in pt. wI systemic bleeding disorders So. No 5 spermatogenes is · Adult : - in adolescence wo any injury - Lymph in Tunica Vaginalis chylocele · 93 % others Bilateral anatomic defect ↑ mobility of testes - in > pt elephantiasis (filariasis) - - - w/ germa. - Sudden testicular Pain. mostly 1 semen.. small ↓ Lymphomaa 20-30 ye , > - NIE : Depend on duration of torsion. e classic - 40 yle 50 % &1. Seminoma 3 Sertoli uspermatocytic. 1. intense congestion - Dilated vein in spermatic cord 1. 2% ~2. Spermatic Seminoma n 60 yo Varicocele. 2 widespread hemorrhage 30 % 3. Embryonal Carcinoma 20-30 yla Bilateral Asymptomatic infertility. - / Lead to ·. - > - CIf :· Testicular dysfunction 3. Testicular infarction - esp if not treated. 4. Endodermal (yolk Sac) -o infant 4 yle · Types : Schoriocarcinomaa Risk of Testicular large · Cancer -fluctuant a , Painless clear fluid in Tunica vaginalis Hydrocele a ins ↳ - (4) transillumination. Malignant Lymphoma of B-cell ↓ -spread widely - CNS involvement Germ cell Tumors = 99 % of all testicular tumors in pt - seminomatous => Atypical cells in seminiferous tubules , No invasion > - Non-seminomatous Tubule - Atypical & - Atepical o ~ ITGEN Normal ITGCN I I Il Type character NE ME Pi C · 93 % of all Seminoma 1 testis X10 its Lymphocytic infiltrate enlarge N Size sheets islends cords of - large. · , cells - Fried egg appearance , : · Peak : 40 ye. N 2 contour -> no invasion to tunica - vesicular nuclei & C l a ss i c Rare B4 puberty. 3 Homogeneous grey - white lobulated clear cytoplasi glycogen) : (↑ , , - small - Sen Seminoma 4. no necrosis + Hemorrhage fibrous stroma "Scanty" · similar to Prognosis. Based 5 on Size : Dysgerminoma Better than other tumors Replace entire testis Lymphocytic infiltrate - - Large : ·. - Highly Radiosensitive S mall - : circumscribed mass in testis large fried-egg appearance egiant cell · u/C - 1-2 % of all germ cell Tumors larger , softer , yellowish more gelatinous than classic. , · pleomorphism - Lymphocyte-like , huge mononucleated , giant cells · in 60 y10 tosinophilic cytoplasm glycogen) 08. · (No spermatocytic P · Round nuclei Seminoma Prognosis ·↑ Mitoses - Excellent ! - bas its slow growing. Rare metastasis - Radiosensitive · No lymphocytes in stroma Mitosis Reomorphism small tumor · , grey-white , soft necrosis · + Hemorrhage ⑳ 30 % of germ cell tumors 1 Tumor cells have many patterns. - gland Tube Papillea solid Distant contour of testis , , , · · Mic in 20-de ye Embryonal ↑ y ⑳ x FP/hca/ both invade tunica + epididymis. 2 Highly Anaplastic - mitoses , giant cells , hemorrhage , necrosis Carcinoma · more aggressive than Seminoma 3 Stroma have primitive. mesenchyme OP necrosis Hemorrhage D invasion Hyaline globules 1. infiltrative 2. yellow-white Schiller-Duval Bodies - glomerulus-likey &. Mucinous 3 1 central vessel similar to endodermal & Sinuses of Rat placenta. germ cell 2 Endodermal · MIC in infants - 4 ye. 3 cystic space "Yolk Sac" · ↑X FP 4. germ cell O > - N Hyaline globules=> x - +P S chiller-Duval Bodies Germ cell Tumors- cont I 11 I Type character NE ME Pic e Syncytiotrophoblast · HighlyMalignant tumor large cell , irregular nuclei , eosinophilic · M/c other w/ germ cell tumor vaculated Syncyto cytoplasm. < choriocarcinoma inLearn Cytotrophoblast Small , Regular , clear/eosinophilic cytoplasm, Hyperchromatic nuclei composed of all Types of Tissues : 1. Ectoderm Teratoma 2. Mesoderm. Endoderm 3 Difference Between testicular + ovarian Teratoma : CIf of germ cell tumors I I - - Testicular Teratoma Svarian Teratoma Painless 3 Types 3. Types enlargement ↓ Hormone/enzyme : : of Testis spread mature"Benignanodermal ↳ Types 1. Mature "Benign" - in child great prognosis Production , " / ↳ear. 2 immature , can't differ & "malignant" -> in post-pubental men. 3 between immature r "Malignant" types of Tumors c inema Pure Rare other cell tumor "So % " Common Teratoma , comes we germ a Dermaid Rave Common Sequenceae Sex-cord Tumors - ↑ steroid hormones feminizing effects musculinizing - I Il I Type character NE ME Pic - unilateral Granulosa Call-Exner bodies & Extremely rare ! - Solid Rosette , central pink mass , cuboidal granules a - white-yellow Call-Exner bodies · in 20-30 y10 · small ( - Malignant : Small hyperchromatic / large wi prominent nucleoi · Hormonally = Testicular Silent Mass & · cutoplasm : Scant , foamy eosinophilic , , lipidized > Lipid Tumor cord · Hyaline globules