Teratogenicity PDF
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Uploaded by AdaptiveHawkSEye
Kent State University
Ezgi G. Berkay
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Summary
This presentation covers teratogenicity, examining factors affecting embryo development and causing birth defects. It details the role of genetics, environmental factors, and teratogens in fetal development.
Full Transcript
Teratogenicity Ezgi G. Berkay, MD, PhD Teratogenic factors affect the development of embryos and cause fetal anomalies. The branch of science dealing with this subject is Teratology. Malformations in the first year of life 65-70% Polygenic multifactorial (the result of gene-environment interaction...
Teratogenicity Ezgi G. Berkay, MD, PhD Teratogenic factors affect the development of embryos and cause fetal anomalies. The branch of science dealing with this subject is Teratology. Malformations in the first year of life 65-70% Polygenic multifactorial (the result of gene-environment interaction) Spontaneous disruption of development Effect by interactions of teratogens 10-25% Genetics - Autosomal and sex-linked genetic diseases - New mutations - Chromosomal 10% Environmental Maternal (4%), Infections (3%), Mechanical reasons (1-2%), Chemicals, drugs, radiation, hyperthermia (
