Heterocyclic Chemistry Lecture 5 PDF

STRUCTURE AND Lecture RECTIVITY OF HETEROCYCLES 5 COURSE NAME: HETEROCYCLIC CHEMISTRY COURSE CODE: CHEM-345 1 Electrophilic Substitution Reactions Five membered heterocycles are more reactive toward elec...

STRUCTURE AND Lecture RECTIVITY OF HETEROCYCLES 5 COURSE NAME: HETEROCYCLIC CHEMISTRY COURSE CODE: CHEM-345 1 Electrophilic Substitution Reactions Five membered heterocycles are more reactive toward electrophiles than benzene Heterocyclic Chemistry Electrophilic Substitution Reactions of Furan Sulfonation Acetylation Chlorination Heterocyclic Chemistry Bromination Nitration Action of Acid Medium 4 Nucleophilic Substitution Reactions of Furan Nucleophilic Substitution Reactions is facilitated by the presence of electron withdrawing group Heterocyclic Chemistry Electrophilic Substitution Reactions of Thiophene Iodination Bromination Nitration Heterocyclic Chemistry Sulfonation Acetylation Effect of Acid Medium 7 Nucleophilic Substitution Reactions of Thiophene Mechanism of Nucleophilic Substitution Heterocyclic Chemistry Other examples of nucleophilic substitution 9 Electrophilic Substitution Reactions of Pyrrole Halogenation Coupling with diazonium salts Acetylation Heterocyclic Chemistry Nitration Sulfonation Mannich Reaction 11 Alkylation Reaction with Grignard Reagents Acetylation Effect of Acid Medium 12 Nucleophilic Substitution Reactions of Pyrrole Nu - No reaction t-ButO K N Cl No reaction H LiAlH4 No reaction Heterocyclic Chemistry Second Electrophilic Substitution Reactions of Five-membered Heterocycles E E+ + N EWG N EWG E N EWG H H H E E+ + N ED N EWG E N EWG H H H EWG EWG E+ E N N H H ED ED E+ E N N H H Heterocyclic Chemistry Thank You 15