Drug Clearance PDF
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This document discusses protein-bound drugs, their elimination processes, and clearance determination. It explains that these drugs are not eliminated by glomerular filtration and that active secretion is a primary route. The determination of drug clearance is a complex process that often requires considering multiple elimination components.
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Protein Bound Drugs Not eliminated by glomerular filtration. Only the free drug is excreted by a linear process. Bound drugs usually excreted by active secretion, following capacity limited determind the kinetics. Determination of clearance...
Protein Bound Drugs Not eliminated by glomerular filtration. Only the free drug is excreted by a linear process. Bound drugs usually excreted by active secretion, following capacity limited determind the kinetics. Determination of clearance which separates two components would result in a hybrid - e drug have When the clearance.=> Icomponent way that have different thisnot of elimination , have No simple way to overcome this problem. 2 example : one have => fitration and other secretion => have
