Cell Cycle and Mitosis I and II Quiz part 1 PDF
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Summary
This document appears to be a set of notes on the cell cycle and mitosis. It includes diagrams, summaries, and discussions of various processes related to cell division. It covers topics such as phases of the cycle, cyclins, and CDKs. The material seems to be geared towards an advanced undergraduate level.
Full Transcript
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"%70@4 "8A=@8@ %?=>70@4 "4A0>70@4 <0>70@4 )4:=>70@40<3FA=98<4@8@ <A4?>70@4 0> 6/=+,853-+55B+-=3?/+7.1;8@371 +-=3?/ 1;8@371 B ) =8) ((F<A74@8@"<B7=2/<3< 0> -/551;8@=2+7.9;/9+;+=38708;!92+</ 1;8@=2 9;/9+;+=387 &* (#)()) D/55</A3= +7.<=89.3?3.371 *&#'% # * ',#,#(' D -/55<;/6+37-+9+,5/80;//7=/;371=2/ -/55-B-5/37;/<987</=8<=36>53=2+==;311/; -/559;8530/;+=387 )'" #!!- '#) )()) D /55<2+?//A3=/.=2/-/55-B-5/9/;6+7/7=5B+7.-+7785871/;.3?3./ D !+7B=B9/<8023125B<9/-3+53C/.-/55<+;/=/;637+55B.300/;/7=3+=/.+7.=2/;/08;/78=-+9+,5/ 80-/55.3?3<387E0;>:4@7/>;87<-+;.3+-6><-5/-/55<<4/5/=+56B803,/;<-3;->5+=371 5/>48-B=/<7/>=;89235</8<3789235<+7.,+<89235< -! #(#-! #%##) #(( F2:8<@ ./ D+635B809;8=/37<=2+=-87=;85<9;81;/<<387 -87=;85<9;81;/<<387 =2;8>12=2/-/55-B-5/ D B-537<,37.<9/-303-+55B=8/7CB6/<-+55/. B-537./9/7./7= 37+</< =808;6 02A8C42=;>:4E4@ D /?/580/+-2-B-537=B9/5:B2AB0A4@ .>;371 .300/;/7=92+</<80=2/-/55-B-5/=8;/1>5+=/ +-=3?3=B80+<9/-303- F2:8<4>4<34<A 8<0@4@ D+635B809;8=/37437+</<=2+=928<928;B5+=/< 928<928;B5+=/< +,;8+.;+71/809;8=/37<>,<=;+=/<45542A=?@ +,;8+.;+71/809;8=/37<>,<=;+=/< ;/:>3;/.=8-8695/=/=2/-/55-B-5/ D /?/5<80 ;/6+37;/5+=3?/5B@A01:4 .>;371 =2/-/55-B-5/ D -=3?+=38780 3<./9/7./7=>98718<38<6 =8 3=<<9/-303--B-537< 0 %#' 0 %#' <02A8C4 2A8C42=;>:4E ' $ # # -! #(#-! #%##) #(( B<2A8=<=5 F2:8<=;>:4E4@ 4::F2:4 F2:8< =;>:4E #2+</ B-537 =8%&;+7<3=387 B-537 %#2+</ B-537 %=8 &;+7<3=387 B-537 =8!&;+7<3=387 B-537!# "0AB?0A8=<%?=;=A8<602A=?"% !#3<+78=2/;7+6/08;=2/ F2:8<-8695/A!#0>7-=387<+<=2/6+<=/;;/1>5+=8; F 6+<=/;;/1>5+=8; 80=2/ =8!=;+7<3=387,B928<928;B5+=3719;8=/37< =8!=;+7<3=387,B928<928;B5+=3719;8=/37<37?85?/.3763=8=3-9;8-/<</<37-5>.371 -2;86+=37-87./7<+=387,;/+4.8@780=2/7>-5/+;/7?/589/+7.08;6+=38780=2/63=8=3-<937.5/ ' *!) $#$ ) + )- " # ("( =?;0A8=<=5 F2:8<=;>:4E4@ B-5375/?/5<05>-=>+=/.>;371.300/;/7=92+</<80 =2/-/55-B-5/&2/+68>7=80/+-2-B-537+?+35+,5/ 08;08;6+=38780+-=3?/ -B-537-8695/A/< 3<;/1>5+=/..>;371=2/-/55-B-5/,B-2+71/<37 3=<@F<A74@8@ +7.346?030A8=< (F<A74@8@ 0 %#' 46?030A8=< >?=A4=:F@8@ '4C4?@81:4%7=@>7=?F:0A8=<=5 F2:8<=;>:4E4@ 0 02A8C0A8<698<0@4 #28<928;B5+=/< <=80>55B02A8C0A4 -B-537-8695/A 1 8<7818A=?F98<0@4@ #28<928;B5+=/ <878=2/;+6378+-3.<=88<7818A =2/+-=3?3=B 80=2/ -B-537-8695/A 232 50;8:F=5>7=@>70A0@4@ 2A8C0A4 -B-537-8695/A/<,B./928<928;B5+=387 32 5 80 < 232 1 <7818A=?F 98<0@4@ % % <7818A43 0 2A8C0A43 % B::F2A8C0A43 ' $ # # ' *!) $#$ ) + )- " # ("( F2:8<4>4<34<A 8<0@4 <7818A=?@ B 9 +635B809;8=/37<=2+=,37.<=8 -B-537-8695/A/<+7. ;/1>5+=/=2/5/?/5<80 < 8<7818A +-=3?3=B ;8@=20+-=8;<;/1>5+=/=2/5/?/5<80 <,B 6>5=395/6/-2+73<6<=2+=-87=;85=2/3;<B7=2/<3<+7../1;+.+=387 0 # 0;8:F=5 @.> > > > / %9/-303-3723,3=8;< 80 0 B-537 B-537 58-4< 92+</ 18> 8>0;8:F=5 @.> ;8+./;;+71/803723,3=387 723,3=< 723,3=< 723,3=< 723,3=< > > / B-537 58-4< =8% B-537 58-4<% B-537 58-4<%=8 B-537 58-4< =8! !!*!'" # ("($!!-!' *!) $# '4@A?82A8=<%=8<A /-3<3879837==2+=8-->;<5+=/37=2/ 92+</ 0+-/559+<</<=2;8>12=23<9837==2/73=,/-86/< -8663==/.=8%92+<//7=;B+7.-8695/=38780 =2/-/55-B-5/ 0%?4@4<24=56?=DA7502A=?@ /55<<=36>5+=/.=8 9;81;/<<=2;8>12 ;/<=;3-=3879837==8%92+</ 11@4<24=56?=DA7502A=?@ /55<<=89+==2/ =2/;/<=;3-=3879837=+7.-+7/7=/; ; '4@A?82A8=<%=8<A ' $ # # !!-!' *!) $# ?=DA702A=?=<A?=: D ;8@=20+-=8;<+-=3?+=/7>6/;8><37=;+-/55>5+;<317+53719+=2@+B<=2+=;/1>5+=/=2/-/55-B-5/ ,B0+-353=+=371=2/ =8%=;+7<3=387=2;8>12=2/;/<=;3-=3879837= ;/-/9=8; ;=B;8<37/437+</ D&23</A+695/<28@<+-=3?+=38780=2/ ;/-/9=8;@23-23<+;/-/9=8;=B;8<37/437+</=2+= 373=3+=/<=2/$+<! !#437+</9+=2@+B $+<! !#437+</9+=2@+B D&2/9;8=/379;8.>-=8087-81/7/<+;/80=/71+37800>7-=3876>=+=387<=2+=;/<>5=3758<<80 -/55-B-5/-87=;85,/-+></80>7;/1>5+=/.9;81;/<<387=2;8>12=2/ ;/<=;3-=3879837= ),(* ,#.,#('( $#'+ 10 %#'+0'," +#+ ,#., (&)% / + '1'4A8<=1:0@A=;064<4>?=3B2A 0;8:F=5)?0<@2?8>A8=<02A=?@ "(+)"(*0%,#('( 00 %#' -+ +#,+ #++( #,#(' *(&,*'+ *#),#(' ,(*+ (')"(+)"(*0%, #' +,(' #'"# #,+ ,*'+ *#),#(' ,(*+ - % -+ *! ,! ' + ,#., +,*'+ *#),#('( ,*! ,! ' + / 0 %#'0 %#' %% 0 % )*(!* ++#(',()"+ 08<38<6=56?=DA7502A=?A=?424>A=? 7.>-/</A9;/<<38780F2:8<=2;8>12=2/ $+< $+0 ! $ <317+53719+=2@+B 18<38<6=5F2:8<A= 0<3 +></<08;6+=38780+-=3?/-8695/A/< 2%7=@>7=?F:0A8=<=5'1>?=A48<1FF2:8< 2=;>:4E4@+></<=2/ .3<<8-3+=38780$,0;86 0+635B80=;+7<-;39=3870+-=8;< 3B<2A8=<=5 !8?/<=87>-5/><+7.+-=3?+=/<=;+7<-;39=38780=+;1/=1/7/<;/:>3;/.08; !8?/<=87>-5/><+7.+-=3?+=/<=;+7<-;39=38780=+;1/=1/7/<;/:>3;/. -/55-B-5/9;81;/<<387=2;8>12=2/;/<=;3-=3879837==8=2/%92+</A+695/<37-5>./B-537 B-537+7.;/1>5+=8;B9;8=/37<80"#85B6/;+</< ' $ # # !!-!' *!) $# #0;064=<A?=:7429>=8<A@ +6+1/-87=;85-2/-49837=<0>7-=387+<+6/-2+73<6=8 0??4@A -B-5/-/559;81;/<<38737;/<987</=8/3=2/;" .+6+1/8;>7;/953-+=/."&2/.+6+1/-87=;85-2/-49837= 37 <28@72/;/3<<=A =2/<+6/+<=2/;/<=;3-=3879837= 04A42A8=<=5#0;064 ;/5+=/.9;8=/37437+</<0>7-=387 9+;=80";/9+3;6+-237/;B,B34A42A8<6#30;064 </+-=3?+=/.,B<371 <3715/<=;+7.,;/+4<'(.+6+1/ H)' 37+</+-=3?+=/.,B<3715/<=;+7.,;/+4<'(.+6+1/ >7;/953-+=/." " 8;,B>7;/953-+=/." .8>,5/<=;+7.,;/+4< H )" 37+</+-=3?+=/.,B.8>,5/<=;+7.,;/+4<37" )"A0E80)4:0<6842A0@80"BA0A43)')" 0<3'03 ?4:0A43 14::F2:4??4@A1F7429>=8<A 8<0@4@ H)'-=3?+=/<2/-49837= 37+</ ,B928<928;B5+=387 928<928;B5+=387 H )"-=3?+=/<2/-49837= 37+</ ,B928<928;B5+=387 928<928;B5+=387 *+8??0380A8=<@8<6:4@A?0<31?409@ =?B<?4>:820A43# )' 2A8C0A8=< =B1:4@A?0<3 1?409@8<# )' )" 2A8C0A8=< )" % % % 32 H 0<3 >7=@>7=?F:0A432 H 32 >7=@>70A0@402A8C8AF8<7818A43 <7818A=?F 98<0@4@ % % <7818A43 H H 8<7818A8=< ??4@A 8<7818A8=< 0<3(??4@A 2A8C4 2A0E80)4:0<6842A0@80!>=+=387<37&!1/7/-+></37+,353=B=8./=/-=.8>,5/<=;+7.,;/+4< 37"87</:>/7=5B 3<78=+-=3?+=/.=8=;311/;-/55-B-5/+;;/<= D %/?/;/7/>;85813-+5.3<8;./;<@2//5-2+3;,B+1/ D +;;3/;<2+?/37-;/+</.</7<3=3?3=B=8*;+B<+7.;+.3+=38737.>-/.,;/+<=-+7-/; ' $ # # !!-!' *!) $# '=:4=5)B;=?(B>>?4@@=? 4<4@ &>68;<>99;/<<8;1/7/</7-8./9;8=/37<=2+=0>7-=38778;6+55B,B;/1>5+=371=2/-/55-B-5/37 1 ;/<987</=8<=36>53<>-2+<".+6+1/ 8<<800>7-=3876>=+=387<6>=+=387<=81=A7 2=>84@ -/55>5+;=;+7<08;6+=387 =>68;./?/5896/7= 80=2/</1/7/<-+7-+></-/55>5+;=;+7<08;6+=387+7.+7.5/+.=8=>68;./?/5896/7= )B;=?(B>>?4@@=? 4<4 5542A=< 4::F2:4 %?=A48< 37.<=8 =;+7<-;39=3870+-=8;<=83723,3= =;+7<-;39=3870+-=8;< =;+7<-;39=387+5+-=3?+=38780=+;1/=1/7/< =3 5 =3 =3 0= = +;;/<= + " 0+635B80 3723,3=< +;;/<= + &;+7<-;39=3870+-=8;37.>-/.,B".+6+1/ &;+7<-;39=3870+-=8;37.>-/.,B".+6+ +-=3?+=/<=;+7<-;39=387809 8=2/;1/7/< =8%+;;/<= 0B<2A8=<=5'1 D )2/7$,3<787928<928;B5+=/.3=,37.<=8 =;+7<-;39=3870+-=8;<+7.3723,3=<+-=3?+=387 80=+;1/=1/7/<;/:>3;/.08;=2/ =8%=;+7<3=387 D)2/7B-5375/?/5<37-;/+</B-537 +7.B-537 -8695/A/<+;/+-=3?+=/. +7.928<928;B5+=/$,@23-2-+></<3==8.3<<8-3+=/0;86 =;+7<-;39=3870+-=8;< 10 %#'+0'," +#+ ,#., (&)% / + "(+)"(*0%,#('( 00 %#' -+ +#,+ #++( #,#(' *(&,*'+ *#),#(' ,(*+ - % -+ (')"(+)"(*0%, #' +,(' #'"# #,+ ,*'+ *#),#(' ,(*+ *! ,! 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' + / 0 %#'0 %#' %% 0 % )*(!* ++#(',()"+ 1B<2A8=<=5> D 9 3<+6/6,/;80 " 0+635B80-B-537./9/7./7=437+</3723,3=8;< 0 " 0+635B D 9 3723,3=<B-537 +7.B-537 58-4< 92+</ D 8<<809 0>7-=387+558@<B-537 +7.B-537 -8695/A/<=8;/6+37+-=3?/ 0 %#' 0 %#' > 0 %#' > > 2A8C4 0 %#' <02A8C4 ??4@A ' $ # # !!-!' *!) $# '=:4=5)B;=?(B>>?4@@=? 4<4@ 2B<2A8=<=5! #=B1:4(A?0<3 ?409@ )" 2A8C0A8=< 9 3<;/0/;;/.=8+<=2/ $ 9 E >+;.3+780=2/ /786/F E >+;.3+780=2/ /786/F!8;/=2+7 80+552>6+7=>68;<-87=+379 6>=+=387< )" % 2A8C4 > 4<4 % > > @A018:8G431F>7=@>7=?F:0A8=< @A018:8G43 :4C4:@8<2?40@4 % 0 %#' > > A=( 1:=2943 (A8;B:0A4A?0<@2?8>A8=< =5A74> 64<4 "=:42B:0?(A?B2AB?4B<2A8=<=5> <2?40@43 4E>?4@@8=< =5> <7818A8=<=5 F2:8< 9 3<+<9/-303-=;+7<-;39=3870+-=8;=2+=+-=3?+=/<=+;1/=1/7/<37?85?/.37;/1>5+=371=2/ -/55-B-5/+7.+989=8<3< # ) %' ) )?0<@02A8C0A8=<=;08<) -=3?+=38780$"#85B6/;+</ 2858/7CB6/ %?=:8<4'827=;08<%' 37.371<3=/08;8=2/;;/1>5+=8;B9;8=/37< #8<38<6=;08< 37.<=8<9/-303-</:>/7-/<80=+;1/=1/7/< )4A?0;4?8G0A8=<=;08< 9 ,37.<=8"+<+=/=;+6/; FA=>:0@;82)08:=;08<) ',3:>3=37+=387<3=/=2+=-87=;85<<=+,353=B809 ' $ # # " )$( ( !3=8<3<3<=2/">70@4 80=2/-/55-B-5/.>;371@23-2=2/-2;868<86/<+;/.3?3././:>+55B 37=8 .3<=37-=7>-5/3 =3<08558@/.,B-B=8437/<3<@23-21/7/;+=/< .+>12=/;-/55<"8=/=2+= B ";/953-+=387+7.-/551;8@=28-->;.>;37137=/;92+</145=?4 =2/ =8!=;+7<3=387 ";/953-+=387 -/551;8@=28-->; ', *)"+ ' ' ' )%# ,#(' #,(+#+ 0,($#' +#+ ' "*(&(+(& )#* #+, * "*(&,# + (A064@=5"8A=@8@ "*(&(+(& (' '+,#(' %#!'& ',('& ,)"+ )%, )*,#('( +#+, * "*(&,# + D#;892+</ D!/=+92+</ D7+92+</ D&/5892+</B=8437/<3< D&;+7<3=387+5<=+1/< #;86/=+92+</+;5B7+92+</+7. +=/7+92+</ %=+1/<8063=8<3<?3<>+53C/.,B05>8;/<-/7==+1<08;-2;86+=37,5>/63-;8=>,>5/<1;//7 +7.37=/;6/.3+=/035+6/7=<;/.
