BMS 1:2 End of Semester Exam Questions PDF

## MARKING SCHEME ### FACULTY OF BIOMEDICAL SCIENCES ### DEPARTMENT OF BIOCHEMISTRY ### BMS 1:2 END OF SEMESTER EXAM QUESTIONS 28th November 2017 ### TIME ALLOWED: 3 HOURS **A: MULTIPLE CHOICE** **INSTRUCTIONS:** Clearly CROSS the correct response on the ANSWER SHEET provided 1. One of the foll...

## MARKING SCHEME ### FACULTY OF BIOMEDICAL SCIENCES ### DEPARTMENT OF BIOCHEMISTRY ### BMS 1:2 END OF SEMESTER EXAM QUESTIONS 28th November 2017 ### TIME ALLOWED: 3 HOURS **A: MULTIPLE CHOICE** **INSTRUCTIONS:** Clearly CROSS the correct response on the ANSWER SHEET provided 1. One of the following is **not** required for the activation of amino acids - tRNA - ATP - Peptidyl transferase - Aminoacyl tRNA synthetase 2. One of the following is **not** a nonsense codon - AUG - UGA - UAA - UGC 3. The primary transcript undergoes all the following **except** - Capping - Splicing - Polyadenylation - Alkylation 4. If the primary transcript is given as GCUUUA, the coding strand is - CGAAAT - CGAAAU - GCTTTA - GCAAAA 5. In the central dogma, the latest input is - DNA replication - Reverse transcription - RNA self-replication - Post-translational modifications 6. In group III introns, one of the following types of proteins participate in splicing - HSP - Chaperones - snRNPs - AP endonuclease 7. One of the following antibiotic agents inhibits prokaryotic protein synthesis: - Puromycin - Actinomycin - Rifampicin - Acridin 8. Cochayne syndrome and Xeroderma pigmentosum result from mutations in - Cell cycle genes - DNA repair genes - Transposable elements - Oncogenes 9. One of the following is **not** a post translational modification - Cleavage of N-terminal sequence - Alkylation - Polyadenylation - Hydroxylation 10. In mismatch repair, one of the following occurs after proofreading - Old strand is hydroxymethylated - Old strand is methylated - New strand is hydroxymethylated - New strand is methylated 11. In the epinephrine cascade, the active form of glycogen phosphorylase is - Dephosphorylated - Phosphorylated - Methylated - Hydroxylated 12. An enzyme that catalyzes the committed step of a pathway is **not** a/an - Allosteric enzyme - Pacemaker enzyme - Restriction enzyme - Regulatory enzyme 13. One of the following hormones **controls** orexia and anorexia - Oxytocin - HCG - Leptin - Insulin 14. In plant cells, an adaptation of amphibolism is - TCA cycle - Glyoxylate cycle - Urea cycle - Pentose phosphate pathway 15. Catabolism of carbohydrates generates all the following **except** - Reducing power - ATP - Macromolecules - Carbon dioxide 16. The preparatory stage of lipid catabolism involves - Lipolysis - ß oxidation - TCA cycle - Electron transfer chain 17. Ketogenic amino acids furnish one of the following metabolites - Glucose - Acetyl coenzyme A - Free fatty acids - ATP 18. Secretion of insulin would normally increase one of the following - Glycogenesis - TCA cycle - Ketolysis - Glycogenolysis 19. One of the following tissues **cannot** utilize ketone bodies - Brain - Skeletal muscle - Liver - Kidney 20. The major energy currency of metabolic activity is - Creatine phosphate - GTP - UTP - ATP 21. Which one of the following classes of enzymes degrade ingested Nucleic acids to Mononucleotides - Phosphodiesterases - Phosphorylases - Endonucleases - Nucleoside deaminase 22. During the salvage and de novo synthesis pathways of purine and pyrimidine biosynthesis, ribose-5-phosphate is activated to? - Phosphorbosyl-5-phosphate - Phosphoribosyl-1-pyrophosphate - Phosphoribosyl-5-pyrophosphate - Phosphoribosyl-1-phosphate 23. The enzyme responsible for activation of ribose -5-phosphate is known as: - Phosphoribosyl-1-pyrophosphate synthetase - Formyl transferase - Phosphoribosylglycinamide formyltransferase - Phosphoribosylglycinamide synthetase 24. PRPP Glutamyl amidotransferase catalyzes the synthesis of--- - PRPP and Glutamine - 5-phosphoribosylamine - 5-PRPPglutamine - 5-PRPP amido glutamyl 25. In the de novo purine biosynthesis, the enzyme which catalyzes three steps is termed as; - IMP synthase - Bifunctional enzyme - ATIC enzyme - Trifunctional enzyme 26. Which one of the following is a branch point for synthesis of purines? - XMP - IMP - GMP ==End of OCR for page 16== <start_of_image> This is only part of the document - the response is truncated due to length limitations. Would you like me to continue?