1.0 Introduction to Pathology .pdf

Unit 1: Introduction to General Histopathology Dr Fred Maate  Definition of pathology Branches of pathology Aspects of Disease Cause (aetiology). Mechanism of development (pathogenesis). Structural alterations (morphology). Functional conseq...

Unit 1: Introduction to General Histopathology Dr Fred Maate  Definition of pathology Branches of pathology Aspects of Disease Cause (aetiology). Mechanism of development (pathogenesis). Structural alterations (morphology). Functional consequences of the above as observed clinically. How disease is studied in histopathology Postmortem cytology histology Request form Multidisciplinary team (MDTs) Infection prevention Ethical aspects in pathology practice Definition of pathology Pathos=suffering Logos=study Branches of pathology Histopathology/anatomical pathology Forensic pathology Clinical pathology Microbiology/mycology, virology, parasitology Chemical pathology Molecular pathology Aspects of disease Etiology Pathologenesis Morphologic changes Functional Derangements and Clinical Manifestations Etiology or cause Genetic or acquired genetic (e.g., inherited mutations and disease-associated gene variants, or polymorphisms) and acquired (e.g., infectious, nutritional, chemical, physical) multifactorial Pathogenesis the sequence of cellular, biochemical, and molecular events that follow the exposure of cells or tissues to an injurious agent. Morphologic Changes the structural alterations in cells or tissues that are either characteristic of a disease or diagnostic of an etiologic process. Functional Derangements and Clinical Manifestations clinical manifestations (symptoms and signs) of disease progress (clinical course and outcome). How disease is studied in histopathology Postmortem cytology histology Request form Multidisciplinary team (MDTs) Infection prevention Universal precautions Biosafety Containment PPE Ethical aspects in pathology practice Anatomical and clinical pathology Forensic pathology  End