1-Drug Discovery and Pre-Clinical Development_PPM May 2024 - Part 1 (1).pdf

Drug Discovery and Pre-Clinical Development Jayant Sancheti, PK Sciences, BR Hyderabad, India May 16,2024 Insert menu > Header & Footer button 1 Disclaimer This presentation is based on publicly available information (including data relating to non-...

Drug Discovery and Pre-Clinical Development Jayant Sancheti, PK Sciences, BR Hyderabad, India May 16,2024 Insert menu > Header & Footer button 1 Disclaimer This presentation is based on publicly available information (including data relating to non- Novartis products or approaches) The views presented are the views of the presenter, not necessarily those of Novartis These slides are intended for educational purposes only and for the personal use of the audience. These slides are not intended for wider distribution outside the intended purpose without presenter approval The content of this slide deck is accurate to the best of the presenter’s knowledge at the time of production 2 Topics What is drug discovery and development What are the different phases of drug discovery and development What is pre-clinical development and its role How these activities support further development What are project milestones and governance board in Novartis 3 Drug Discovery 4 What is a drug, drug discovery and development ? What is a drug? Plants Ex:Digitalis Any substance, other than food, used in the prevention, diagnosis, or treatment of a disease Minerals Ex: Iron, calcium Synthetic Ex: Apirin What is drug discovery? The process through which a new chemical entities are discovered as a potential therapeutic agent 5 What is drug development? Basic Program in Pharmaceutical Medicine Animals Ex: Insulin Semisynthetic Ex: Etoposide, paclitaxel, codiene The process of bringing a lead compound (from Microorganisms Ex: Penicillin: Penicillium notatum discovery) to the market by testing safety and efficacy in human with a suitable formulation 5 What makes a good drug A good drug targets an unmet medical need It By cure a disease or the symptoms of the disease should By stop the progression of the disease work Quickly and with no complicated dosing regimen Does not cause any serious adverse side effects or long-term toxicity Safe to Does not alter the pharmacology of the other medications use Does not have its own pharmacology altered by other drugs Cost Economically viable 6  Drug discovery and development is a high-risk undertaking with high attrition Process is expensive and carries high risk (low success rate ( Header & Footer button 30 Thank you