Ross University School of Veterinary Medicine PHARMACEUTICS Drug Formulation PDF Summer 2024

PHARMACEUTICS Drug formulation VPP 5343 I PHARMACOLOGY Ronan CHAPUIS, DEDV, MSc, DACVIM-LA I [email protected] I Google Scholar SUMMER 2024 DISCLOSURE The author declares no conflict of interest The references of the pictures’ copyright are NOT all from professional sources Let’s build strong...

PHARMACEUTICS Drug formulation VPP 5343 I PHARMACOLOGY Ronan CHAPUIS, DEDV, MSc, DACVIM-LA I [email protected] I Google Scholar SUMMER 2024 DISCLOSURE The author declares no conflict of interest The references of the pictures’ copyright are NOT all from professional sources Let’s build strong material at Ross: reach out if you believe there is mistake in the material Acknowledgement: Dr. Melissa Bucknoff Ronan C. VPP 5343, SUMMER 2024 2 OBJECTIVES Identify dosage forms of drugs Identify when label name of the product does not reflect the accurate dosage form Recall important consideration when administering tablets, capsule, & liquid forms Recall factors that can deteriorate drugs Identify on label factors that can deteriorate drugs (storage condition…) Recall that conditions deteriorating drug varies between formulation of drugs Ronan C. VPP 5343, SUMMER 2024 3 Solids Liquids & semisolids Aerosol DOSAGE FORMS Gases Controlled Internal Drug Release System Ronan C. VPP 5343, SUMMER 2024 4 Solids Medicated feed Liquids & semisolids Aerosol DOSAGE FORMS Gases Controlled Internal Drug Release System Ronan C. VPP 5343, SUMMER 2024 5 DOSAGE FORMS Powder Tablets / pill Compressed powder Immediate release: dissolve in gastrointestinal content Modified release Do not crush if enteric coated Extended release Delayed release: enteric coated, protect from action of gastric juice Chewable tablets Bolus: large tablet that remain in rumen Density (app. 3g/cm3) prevent regurgitation during rumination Slow dissolution Implant: small tablet, remain in body for many months Granulation of powder – granule Ronan C. VPP 5343, SUMMER 2024 6 Ronan C. VPP 5343, SUMMER 2024 7 Ronan C. VPP 5343, SUMMER 2024 8 DOSAGE FORMS Capsule: drug enclosed in a shell Hard shell: usually filled with powder Soft shell: usually filled with liquid Do not open if shell is gastroprotectant Suppository Ronan C. VPP 5343, SUMMER 2024 9 Solids Medicated feed Liquids & semisolids Aerosol DOSAGE FORMS Gases Controlled Internal Drug Release System Ronan C. VPP 5343, SUMMER 2024 10 Veterinary feed additives Categories: I: does not require withdrawal time II: require withdrawal time Types: A: most concentrated, used to manufacture the types B & C B: premixes of nutritional supplements & medicated feed C: complete feed that can be fed alone Include premix, medicated blocks Ronan C. VPP 5343, SUMMER 2024 11 Solids Medicated feed Liquids & semisolids Aerosol DOSAGE FORMS Gases Controlled Internal Drug Release System Ronan C. VPP 5343, SUMMER 2024 12 DOSAGE FORMS Liquid Solution: complete dissolution of drug in the liquid phase Suspension: solid particles in a liquid vehicle Mixture, tincture, spirit, elixir, emulsion, extract, infusion, decoction, liniment, lotion For parenteral use: use only labelled product for this route Ronan C. VPP 5343, SUMMER 2024 13 DOSAGE FORMS Semisolid Ointment Cream Paste Emulsion Gels Lotions Ronan C. VPP 5343, SUMMER 2024 14 Solids Medicated feed Liquids & semisolids Aerosol DOSAGE FORMS Gases Controlled Internal Drug Release System Ronan C. VPP 5343, SUMMER 2024 15 DOSAGE FORMS Aerosol: suspension of fine solid or liquid particles in air or another gas Spray Mist … Ronan C. VPP 5343, SUMMER 2024 16 Solids Medicated feed Liquids & semisolids Aerosol DOSAGE FORMS Gases Controlled Internal Drug Release System Ronan C. VPP 5343, SUMMER 2024 17 DOSAGE FORMS Gases Ronan C. VPP 5343, SUMMER 2024 18 Solids Medicated feed Liquids & semisolids Aerosol DOSAGE FORMS Gases Controlled Internal Drug Release System Ronan C. VPP 5343, SUMMER 2024 19 Intravaginal insert (progesterone-impregnated silicone skin) Ronan C. VPP 5343, SUMMER 2024 20 Factors that may alter drugs STORAGE Ronan C. VPP 5343, SUMMER 2024 21 Environment Ambient temperature Exposure to light Photodegradation Humidity Ronan C. VPP 5343, Spring 2023 22 Ronan C. VPP 5343, SUMMER 2024 23 Ronan C. VPP 5343, SUMMER 2024 24 QUESTIONS Ronan C. VPP 5343, SUMMER 2024 28 THANK YOU VETERINARY.ROSSU.EDU ©2021 Ross University School of Veterinary Medicine. All rights reserved.