Thyroid Drugs Part 5.docx

**Slide 25: Hyperthyroidism - Causes** 1. **Which of the following is the most common cause of hyperthyroidism?** - A. Graves' disease - B. Toxic multinodular goiter - C. Thyroid cancer - D. Thyroiditis\ **Answer:** A. Graves' disease 2. **Which symptom is...

**Slide 25: Hyperthyroidism - Causes** 1. **Which of the following is the most common cause of hyperthyroidism?** - A. Graves' disease - B. Toxic multinodular goiter - C. Thyroid cancer - D. Thyroiditis\ **Answer:** A. Graves' disease 2. **Which symptom is typically associated with hyperthyroidism?** - A. Cold intolerance - B. Weight gain - C. Palpitations - D. Constipation\ **Answer:** C. Palpitations 3. **Which laboratory finding is expected in hyperthyroidism?** - A. Elevated TSH and low T3/T4 - B. Low TSH and high T3/T4 - C. Normal TSH with low T3/T4 - D. Elevated TSH and elevated reverse T3\ **Answer:** B. Low TSH and high T3/T4 **Slide 26: Thioamides - Mechanism of Action** 1. **Which of the following is the mechanism of action of Methimazole?** - A. Inhibition of iodine organification - B. Inhibition of TSH release - C. Enhancement of T4 synthesis - D. Stimulation of iodine uptake\ **Answer:** A. Inhibition of iodine organification 2. **Which drug also inhibits the conversion of T4 to T3 in peripheral tissues?** - A. Methimazole - B. Propylthiouracil (PTU) - C. Levothyroxine - D. Liothyronine\ **Answer:** B. Propylthiouracil (PTU) 3. **In what situation is Propylthiouracil (PTU) preferred over Methimazole?** - A. During the second trimester of pregnancy - B. In cases of thyroid storm - C. In patients allergic to levothyroxine - D. For long-term hyperthyroidism treatment\ **Answer:** B. In cases of thyroid storm **Slide 27: Methimazole** 1. **What is the typical maintenance dose of Methimazole for treating hyperthyroidism?** - A. 50-100 mg daily - B. 5-15 mg daily - C. 30-60 mg daily - D. 100-200 mg daily\ **Answer:** B. 5-15 mg daily 2. **Why is Methimazole contraindicated in the first trimester of pregnancy?** - A. Risk of fetal hypothyroidism and birth defects - B. Risk of maternal hypercalcemia - C. Increased risk of preeclampsia - D. Decreased efficacy in pregnant patients\ **Answer:** A. Risk of fetal hypothyroidism and birth defects 3. **How long does it typically take for T4 and T3 levels to drop after starting Methimazole therapy?** - A. 1-2 days - B. 2-3 weeks - C. 4-6 weeks - D. 3 months\ **Answer:** B. 2-3 weeks