Thyroid Drugs Part 6.docx

\#\#\# \*\*Slide 31: Thioamides - Adverse Effects\*\* 1\. \*\*What is the most serious adverse effect associated with methimazole and PTU?\*\* \- A. Hepatotoxicity \- B. Agranulocytosis \- C. Hypoglycemia \- D. Hypercalcemia \*\*Answer:\*\* B. Agranulocytosis 2\. \*\*Which symptom should prom...

\#\#\# \*\*Slide 31: Thioamides - Adverse Effects\*\* 1\. \*\*What is the most serious adverse effect associated with methimazole and PTU?\*\* \- A. Hepatotoxicity \- B. Agranulocytosis \- C. Hypoglycemia \- D. Hypercalcemia \*\*Answer:\*\* B. Agranulocytosis 2\. \*\*Which symptom should prompt urgent medical evaluation in a patient taking methimazole or PTU?\*\* \- A. Diarrhea \- B. Sore throat and fever \- C. Weight gain \- D. Hair loss \*\*Answer:\*\* B. Sore throat and fever 3\. \*\*Which liver condition is associated with propylthiouracil (PTU)?\*\* \- A. Cholestatic liver dysfunction \- B. Allergic hepatitis \- C. Fatty liver disease \- D. Cirrhosis \*\*Answer:\*\* B. Allergic hepatitis \-\-- \#\#\# \*\*Slide 32: Thioamides - Monitoring and Lab Testing\*\* 1\. \*\*What baseline lab test should be performed before starting thioamide therapy?\*\* \- A. Serum creatinine \- B. TSH and Free T4 \- C. Serum glucose \- D. Serum calcium \*\*Answer:\*\* B. TSH and Free T4 2\. \*\*When should a CBC with differential be checked in patients taking thioamides?\*\* \- A. At baseline and anytime symptoms of agranulocytosis appear \- B. Only when symptoms of liver dysfunction occur \- C. Once every 6 months \- D. After 3 months of therapy \*\*Answer:\*\* A. At baseline and anytime symptoms of agranulocytosis appear 3\. \*\*What should be monitored regularly in patients on thioamide therapy to assess for liver injury?\*\* \- A. Serum potassium \- B. Liver enzymes (LFTs) \- C. Blood urea nitrogen (BUN) \- D. Urine output \*\*Answer:\*\* B. Liver enzymes (LFTs) \-\-- \#\#\# \*\*Slide 33: Iodides - Clinical Uses\*\* 1\. \*\*Which of the following is an indication for iodide use in thyroid disease management?\*\* \- A. To reduce the size and vascularity of the thyroid gland before surgery \- B. To increase thyroid hormone production in hypothyroidism \- C. As monotherapy for long-term control of hyperthyroidism \- D. To prevent thyroid hormone release during radioactive iodine therapy \*\*Answer:\*\* A. To reduce the size and vascularity of the thyroid gland before surgery 2\. \*\*How do large doses of iodide inhibit thyroid hormone release?\*\* \- A. By increasing thyroglobulin synthesis \- B. By inhibiting organification and blocking thyroid hormone synthesis \- C. By stimulating TSH release from the pituitary gland \- D. By increasing iodine uptake by the thyroid \*\*Answer:\*\* B. By inhibiting organification and blocking thyroid hormone synthesis 3\. \*\*Which condition is a contraindication for iodide use in thyroid disease?\*\* \- A. Pregnancy \- B. Hyperthyroidism \- C. Graves' disease \- D. Diabetes mellitus \*\*Answer:\*\* A. Pregnancy \-\-- \#\#\# \*\*Slide 34: Iodides - Adverse Effects\*\* 1\. \*\*Which of the following is a disadvantage of iodide use in thyroid storm management?\*\* \- A. Short duration of effect \- B. Delayed onset of symptom improvement \- C. Risk of hyperkalemia \- D. Inability to combine with thioamides \*\*Answer:\*\* B. Delayed onset of symptom improvement 2\. \*\*What is the typical duration of iodide's effect on thyroid hormone synthesis?\*\* \- A. 2 weeks \- B. 4 weeks \- C. 8 weeks \- D. 12 weeks \*\*Answer:\*\* A. 2 weeks 3\. \*\*Why should iodides not be used alone for long-term hyperthyroidism management?\*\* \- A. Because they can cause hypothyroidism \- B. Because their effect on thyroid hormone release lasts only a few weeks \- C. Because they cause irreversible thyroid damage \- D. Because they increase the risk of thyroid storm \*\*Answer:\*\* B. Because their effect on thyroid hormone release lasts only a few weeks \-\-- \#\#\# \*\*Slide 35: Beta-blockers in Hyperthyroidism\*\* 1\. \*\*What is the primary use of beta-blockers in the management of hyperthyroidism?\*\* \- A. To inhibit thyroid hormone synthesis \- B. To manage symptoms like tachycardia and anxiety \- C. To block iodine uptake in the thyroid \- D. To prevent agranulocytosis \*\*Answer:\*\* B. To manage symptoms like tachycardia and anxiety 2\. \*\*Which beta-blocker is most commonly used in the management of hyperthyroid symptoms?\*\* \- A. Atenolol \- B. Metoprolol \- C. Propranolol \- D. Carvedilol \*\*Answer:\*\* C. Propranolol 3\. \*\*At what dose of propranolol does it start inhibiting the peripheral conversion of T4 to T3?\*\* \- A. 80 mg/day \- B. 100 mg/day \- C. 160 mg/day \- D. 240 mg/day \*\*Answer:\*\* C. 160 mg/day