Sjogren Syndrome MCQs PDF

**MCQs on Sjögren Syndrome** **1. What is the primary characteristic of Sjögren Syndrome?**\ A) Inflammation of synovial joints\ B) Lymphocytic infiltration of salivary and lacrimal glands\ C) Autoimmune destruction of pancreatic cells\ D) Hypertrophy of the thyroid gland **2. Which of the followi...

**MCQs on Sjögren Syndrome** **1. What is the primary characteristic of Sjögren Syndrome?**\ A) Inflammation of synovial joints\ B) Lymphocytic infiltration of salivary and lacrimal glands\ C) Autoimmune destruction of pancreatic cells\ D) Hypertrophy of the thyroid gland **2. Which of the following is a common age range for Sjögren Syndrome diagnosis?**\ A) 20--30 years\ B) 30--40 years\ C) 40--50 years\ D) 60--70 years **3. What is the female-to-male ratio in Sjögren Syndrome prevalence?**\ A) 3:1\ B) 5:1\ C) 9:1\ D) 12:1 **4. What is the hallmark symptom of keratoconjunctivitis sicca in Sjögren Syndrome?**\ A) Itching eyes\ B) Dry eyes\ C) Watery discharge\ D) Double vision **5. Which classification of Sjögren Syndrome involves associations with other autoimmune diseases?**\ A) Primary Sjögren Syndrome\ B) Secondary Sjögren Syndrome\ C) Tertiary Sjögren Syndrome\ D) Idiopathic Sjögren Syndrome **6. Which autoimmune diseases are commonly associated with secondary Sjögren Syndrome?**\ A) Diabetes mellitus\ B) Rheumatoid arthritis and systemic lupus erythematosus\ C) Hyperthyroidism and Grave's disease\ D) Multiple sclerosis and Parkinson's disease **7. What is the most commonly used diagnostic test for dry eyes in Sjögren Syndrome?**\ A) Lip biopsy\ B) Schirmer tear test\ C) HRCT scan\ D) Rheumatoid factor assay **8. What histological finding is diagnostic in a salivary gland biopsy for Sjögren Syndrome?**\ A) Macrophage infiltration\ B) Lymphocytic infiltration\ C) Fibrotic nodules\ D) Neutrophilic infiltration **9. Which antibody is found in approximately 70% of Sjögren Syndrome patients?**\ A) Anti-Sm antibody\ B) Anti-La antibody\ C) Anti-Ro antibody\ D) Anti-Jo-1 antibody **10. Which of the following is NOT a clinical manifestation of Sjögren Syndrome?**\ A) Dry mouth\ B) Peripheral neuropathy\ C) Hyperthyroidism\ D) Vaginal dryness **11. Which investigation is primarily used to evaluate renal involvement in Sjögren Syndrome?**\ A) ESR test\ B) HRCT scan\ C) 24-hour urine collection\ D) Skin biopsy **12. What is the primary purpose of hypromellose in managing Sjögren Syndrome?**\ A) Treating dry mouth\ B) Treating keratoconjunctivitis sicca\ C) Reducing fatigue\ D) Stimulating saliva production **13. Which of the following is NOT a common extra-glandular manifestation of Sjögren Syndrome?**\ A) Arthralgia\ B) Pulmonary fibrosis\ C) Dysphagia\ D) Cardiac arrhythmias **14. What is the gold standard for confirming Sjögren Syndrome diagnosis?**\ A) Schirmer tear test\ B) Lip or salivary gland biopsy\ C) Rheumatoid factor assay\ D) Saxon test **15. Which symptom is most commonly associated with interstitial lung disease in Sjögren Syndrome?**\ A) Chronic cough\ B) Hemoptysis\ C) Sudden dyspnea\ D) Fever **16. What is the risk of lymphoma in Sjögren Syndrome attributed to?**\ A) Chronic inflammation\ B) Lymphocytic infiltration\ C) Immunosuppressant therapy\ D) Vascular involvement **17. What condition does the Saxon test evaluate in Sjögren Syndrome patients?**\ A) Dry eyes\ B) Dry mouth\ C) Peripheral neuropathy\ D) Arthralgia **18. Which of the following treatments is used for vaginal dryness in Sjögren Syndrome?**\ A) Artificial saliva\ B) Lacrimal substitutes\ C) Vaginal lubricants\ D) Immunosuppressants **19. What percentage of Sjögren Syndrome patients typically show positive ANA serology?**\ A) 50%\ B) 60%\ C) 70%\ D) 90% **20. Which organ system is primarily targeted in Sjögren Syndrome?**\ A) Nervous system\ B) Exocrine glands\ C) Endocrine glands\ D) Musculoskeletal system