Oxygen Supply and Demand Worksheet (with answers) PDF

Label the typical pO2 in these different areas What formula can be used to Atmosp...

Label the typical pO2 in these different areas What formula can be used to Atmosphere: 21 kPa calculate the total oxygen content Trachea: 20 kPa of the blood? (don’t worry about the specific numbers but try to show the Alveolus: 13 kPa concept) Arterial blood plasma: 11- O2 Oxygen content of Hb 13 kPa Mitochondrion: 1.5 kPa (high) + Oxygen content Venous blood plasma: 6 of plasma (low) kPa By Artwork by Holly Fischer - http://open.umich.edu/edu cation/med/resources/sec ond-look-series/materials - Respiratory Tract Slide 25, CC BY 3.0, https://commons.wikimedi Main type of tissue a.org/w/index.php? Explain how stimulation of adrenergic curid=24367138 Example cause Explain what factors ensure that oxygen is hypoxia receptors can improve oxygenation of 1 Hypoxic Severe lung disease unloaded at tissues that need it the most? tissues that need it the most? (Hint: think (Hint: think back to respiratory interactive session) back to large group cardiovascular EBL session) 2 Anaemic Haemorrhage 3 Ischaemic Arterial occlusion Increase in CO  Increase BP  pH increase perfusion 2,3DPG (glycolysis in 4 Histiotoxic (rare) Cyanide poisoning RBCs) Increase in SVR  Increase BP  allow for increased perfusion if local arterial Temp Bohr shift/Bohr Adrenaline Noradrenaline beds dilate pCO2/pO2 Effect Alpha 1 Medium (variable) High affinity Show which adrenergic receptors are What molecule is clinically measured in the Beta 1 affinity High High most activated by vasopressors and blood to assess if there is insufficient tissue positive inotropes. Describe their oxygenation around the body? What Beta 2 affinity High Low primary actions on heartrate, systemic metabolic process does it tell us has vascular resistance and blood pressure happened (Hint: think back to respiratory interactive session) Vasopressor Positive Inotrope Adrener gic Alpha 1 Beta 1 Lactic acid receptor Heart Minimal effect Increase (if beta 1 (Lactate) Rate Vascular agonist) Anaerobic respiration (non- Resistan Increase Minimal effect oxidative phosphorylation) ce Blood pressure Increase Increase