Molecular Bio & Immunology PDF

Classification of antibodies Type of IgD IgM IgA IgG IgE antibodies Heavy δ (delta) Μ (muy) ɑ (alpha) γ (gamma) ε (epsilon) chain Structure Monomer Pentamer...

Classification of antibodies Type of IgD IgM IgA IgG IgE antibodies Heavy δ (delta) Μ (muy) ɑ (alpha) γ (gamma) ε (epsilon) chain Structure Monomer Pentamer 2 main forms: monomer Monomer -Monomeric: in J chain blood (serum) 3 heavy linking each -Dimeric(secretory chain domain monomer IgA) having J chain and 3 heavy secretory chain component domains Secretory component: by epithelial cells => IgA transportation and protection from proteolytic enzymes Where? B cell surface Blood -Monomeric: in blood and Under skin and blood (serum) extracellular mucous spaces membrane Dimeric in Secretion fluid in respiratory and gastrointestinal tract Functions On surface of predominant The major bind on surface mature B cell, "early" antibody Mucosal immunity antibody of the of basophil and serves as B cell secondary mast cells => Most primitive immune receptor for Ag allergy or immunoglobulin response hypersensitivity May play role in Naive B cell Only Ab class antigen-stimulat antigen that can pass Cooperate with ed lymphocyte receptor placenta eosinophil for differentiation (monomeric immunity to form) helminthic Classical parasites pathway Classical complement pathway activation complement activation Affinity None None None Change with None maturation time % of Trace amount