Otic Medications Module 9 Unit C 2024 PDF

Module 9 Unit C Optic Class Drug examples Indications MOA Safety considerations BBW Notes Generic/Trade contraindications...

Module 9 Unit C Optic Class Drug examples Indications MOA Safety considerations BBW Notes Generic/Trade contraindications D2D QT Acute Otitis Externa Drying agents 2% solution of Superficial infections of Acetic acid is SE/Adverse effects -None Pregnancy/lactation: acetic acid (Acetic the external auditory antibacterial and - Stinging or burning may noted Safe Acid) canal caused by antifungal; be noted occasionally; organisms susceptible to propylene glycol is local irritation has the action of the hydrophilic and occurred very rarely antimicrobial. Otitis provides a low ***Do not use with Externa. surface tension; Contraindications: ruptured TM benzethonium - Hypersensitivity to acetic chloride is a acid or any of the surface active agent ingredients. that promotes - Perforated tympanic contact of the membrane solution with tissues Caution: - Transient stinging or burning may be noted occasionally when the solution is first instilled into the acutely inflamed ear. D2D interactions: - None specified  QT prolongation/Risk of TdP - None Drying Acetic acid 2% Superficial infections of Acetic acid is SE/Adverse effects - None -Pregnancy/ agent/steroid solution and the external auditory antibacterial and - Stinging or burning may noted lactation: Caution, not hydrocortisone 1% canal caused by antifungal; be noted occasionally; enough evidence. (Hydrocortisone organisms susceptible to hydrocortisone is local irritation has and Acetic Acid the action of the anti-inflammatory, occurred very rarely solution) antimicrobial, antiallergic and ***Do not use with complicated by antipruritic; Contraindications: ruptured TM inflammation. Otitis propylene glycol is - Hypersensitivity to Externa. hydrophilic and Hydrocortisone and Acetic acid + provides a low Acetic Acid or any of the propylene glycol + surface tension; ingredients; herpes hydrocortisone benzethonium simplex, vaccinia and (VoScol). chloride is a varicella. Perforated surface active agent tympanic membrane is that promotes considered a contact of the contraindication to the solution with tissues. use of any medication in the external ear canal - Do not use if TM is not intact. Caution: - Discontinue promptly if sensitization or irritation occurs.  - Transient stinging or burning may be noted occasionally when the solution is first instilled into the acutely inflamed ear. - Has not been studied in those less than 3 years old. D2D interactions - None specified QT prolongation/Risk of TdP - None Antibiotics Ciprofloxacin Acute otitis externa due Act by interfering SE/Adverse effects: -None Pregnancy/lactation: No (Ciprofloxacin to susceptible isolates with DNA gyrase - Application site pain, ear note good studies, do not use. Otic drops) of Pseudomonas which is the pruritus, fungal ear aeruginosa or Staphylococc enzyme responsible superinfection, and us aureus. Moderate to for the stranding of headache, each reported severe otitis externa. bacterial DNA in approximately 2-3% of synthesis, as well as patients bacterial growth **Sterile and replication. Contraindications: They are - Known allergy or bactericidal. sensitivity to Cipro Caution: - Otic use only - Growth of superinfection  D2D interactions: - No clear information when taken this route. Refer to oral preparation in Module 2, Unit A QT prolongation/Risk of TdP: - Known risk when taken orally, assume this route as well Antibiotic Ciprofloxacin+ Acute otitis externa in Act by interfering SE/Adverse effects: - None -Pregnancy/lactation: No steroid combo hydrocortisone adult and pediatric with DNA gyrase - Cipro-HC: Headaches, noted good evidence, do no (CIPRO-HC otic) patients, one year and which is the migraine, hypesthesia, not use. older, due to susceptible enzyme responsible paresthesia, fungal strains of Pseudomonas for the stranding of dermatitis, cough, rash, aeruginosa, bacterial DNA urticaria, and alopecia Staphylococcus aureus, synthesis, as well as - Cortisporin: burning, and Proteus mirabilis. bacterial growth itching, irritation, and replication. ***Non-Sterile, do not dryness, folliculitis, use with ruptured TM They are bactericidal. hypertrichosis, acneiform A corticosteroid, eruptions, has been shown to hypopigmentation, Neomycin and Superficial bacterial suppress perioral dermatitis, Polymyxin B and infections of the inflammation by allergic contact Hydrocortisone external auditory canal inhibiting multiple dermatitis, maceration of otic suspension caused by organisms inflammatory the skin, secondary (Cortisporin) susceptible to the action cytokines resulting infection, skin atrophy, of the antibiotics, and in decreased striae and miliaria for the treatment of edema, fibrin infections of deposition, Contraindications:  mastoidectomy and capillary leakage, - History of fenestration cavities and migration of hypersensitivity to caused by organisms inflammatory cells ciprofloxacin, to other susceptible to the quinolones, or to any of antibiotics the components in this medication. - In viral infections of the external canal, including herpes simplex infections and fungal otic infections. - Do not use if TM is not intact Caution: - Otic use only - Growth of superinfection D2D interactions: - No specific mention QT prolongation/Risk of TdP: - Known risk when taken orally, assume this route as well Both Acute Otitis Media and Externa Antibiotics/Ster Ciprofloxacin + -Acute Otitis Media Cipro: The SE/Adverse effects: -None -Pregnancy/Lactation: oid Combo: dexamethasone (AOM) in pediatric bactericidal action - Hypersensitivity noted Not enough data, do not Topical (Ciprodex Otic) patients (age 6 months of ciprofloxacin Reactions use. and older) with results from tympanostomy tubes interference with - Overgrowth of bacteria due to Staphylococcus the enzyme, DNA with prolonged use **Note: This is best for a aureus, Streptococcus gyrase, which is - Ear pruritus, debris, ruptured TM!!! pneumoniae, Haemophilus needed for the congestion, pain, influenzae, Moraxella synthesis of erythema. **Sterile catarrhalis, bacterial DNA - Can lead to disseminated and Pseudomonas herpes infection if there aeruginosa. For use if Dexamethasone: A is a misdiagnosis and it is the patient has corticosteroid, has ruptured TM been shown to called otitis externa and suppress it truly is not. -Acute Otitis Externa inflammation by Contraindications: (AOE) in pediatric (age inhibiting multiple - History of 6 months and older), inflammatory hypersensitivity to adult and elderly cytokines resulting ciprofloxacin, to other patients due in decreased to Staphylococcus edema, fibrin quinolones, or to any of aureus and Pseudomonas deposition, the components in this aeruginosa capillary leakage, medication. and migration of - In viral infections of the inflammatory cells external canal, including herpes simplex infections and fungal otic infections. Caution: - If onset of rash, discontinue. - Continued otorrhea - Superinfection with prolonged use  D2D interactions: - None noted for this route of administration QT prolongation/Risk of TdP: - Known risk when taken orally, assume this route as well Resources: Textbook Lexicomp LactMed CredibleMeds