Mitosis PDF - Veterinary Medicine

Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students Mitosis Cell cycle consists of: interphase stage and division stage ...

Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students Mitosis Cell cycle consists of: interphase stage and division stage  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students Interphase stage  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students Division stage (Mitosis) Definition: -Equational division begin at zygote stage and continue throughout life occur in somatic cells producing two daughter cells contain the same amount of genetic information as in mother cell (2n). Significance: Growth of organism. Tissue replacement and wound healing.  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students phases of mitosis 1- Prophase stage Interphase stage prophase stage  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students 1- Prophase stage -Longest stage takes 1/3 duration. -Centrioles migrate to the opposite poles and formation of spindle fibers. -Nuclear membrane and nucleolus disappear (disintegrate). -The uncoiled, non-condensed, thin, interphase chromosome (chromatin) becomes coiled, condensed, thick, thread like, visible and can be seen under microscope. -Each chromosome consists of 2 sister chromatids attached by common centromere.  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students METAPHASE STAGE -2 PROPHASE METAPHASE  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students 2- Metaphase -chromosomes migrate to the middle zone of the cell and arranged (line up) (align) in the equatorial plane. -Spindle fibers bind to centromere of each chromosome. -Chromosome is best visualized so it is the best stage for karyotyping (chromosomal studies).  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students 3- Anaphase stage Metaphase Anaphase  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students 3-Anaphase -The shortest and the most critical stage. -Centromere of each chromosome divides. -Sister chromatids separate and move to the opposite poles, the centromere act as a leader and chromosome arm act as lagging.  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students 4- Telophase stage  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students 4-Telophase -Cytokinesis (division of cytoplasm) producing cell furrow. -Spindle fibers disappear. -Nuclear membrane and nucleolus reform. -The produced cells contain the same amount of genetic information as mother cell (2n).  Faculty of Veterinary Medicine Department of Husbandry and Development of Animal Wealth VADLs Program – Genetics and Genetic Engineering– 1th Level Students.