Drugs for Atherosclerosis Prevention PDF
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This document details the different drug classes used for the prevention of atherosclerosis, including their mechanisms of action, adverse effects, and therapeutic uses. It covers statins, sterol absorption inhibitors, fibric acid derivatives, and bile acid binding resins. The information appears to be from a biology or chemistry course.
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for Atherosclerotis Prevention Drugs : drug class · mechanism of action Inhibit HMG-Co...
for Atherosclerotis Prevention Drugs : drug class · mechanism of action Inhibit HMG-Co adverse effect myopathy /Improper first therapeutic effect/use line treatment function for lowering LDL ↳ rate limiting step musch statins in cholesterol synthesis· ↑ liver enzymes cholesterol levels Censures more is removed than produced · inhibits transporte · typically used w/ Stero Absorption in GI responsible statins Inhibitor for Cholestero absorption (ex Ezetimibe) ↳ levels plasma · reduces VLDL levels by : rashes treate hypertriglyceridemia · Fibric Acid O ↑ breakdown of · El upset 14 triglycerides3 VLDL) Derivatives pancreatitis triglycerides in myopathy · · /ex , gemEbrozil) &I VLDL secretion · hyperkalemia genfibrozil used to by liver, freut ↑ cholesterol ③ I breakdown of fatty acids in adipose tissue > - bind bile acids · bloating ↓ LDL (20 1 ).. Bile Acid In Intestine , inhibiting Constipation · Binding their reabsorption , Resing their enhancing (ex Cholestyramine). excretion a ↳ cholesterol - > bile in liver , ↓ LDL-cholesterol 100 % 1) monoclonal mild hyperlipoproteinemia > - > - they are skin rxn antibodies targeted against upper resp ↳ ↓ LDL by 60 -70 % peSka the pasha protein tract infection when other drugs don't Inhibitors 4 > - the livers limitation = $$ work (last resort drug) , lex Alirocumab and. ability to remove difficulty wh ↳ if super high LDL Evolocumab) cholesterol from compliance (infection or issues I compliance blood 2-4 weeks) every
