Glycolysis.pdf

Glycolysis Glucose Hexokinase ATP Used Glucose-6-Phosphate Overall= 2x Pyruvate, 2x H+, 2x NADH and 2x H2O Phosphoglucose isomerase Fructose-6-Phosphate Phosphofructokinase ATP Used Fructose-1,6-P bisphosphate Regulation Fructose bisphosphate aldose Activated by low ATP and high AMP Dihydroxyacetone...

Glycolysis Glucose Hexokinase ATP Used Glucose-6-Phosphate Overall= 2x Pyruvate, 2x H+, 2x NADH and 2x H2O Phosphoglucose isomerase Fructose-6-Phosphate Phosphofructokinase ATP Used Fructose-1,6-P bisphosphate Regulation Fructose bisphosphate aldose Activated by low ATP and high AMP Dihydroxyacetone (DHAP) Glyceraldehyde-3-Phosphate (GA3P) triose phosphate isomerase NAD+ + Pi----> NADH + H+ - Regulation occurs with phosphofructosekinase which is activated by AMP and inhbited by ATP and converts fructose 6-phosphate into fructose 1,6-bisphosphate. - Regulation also occurd at level of pyruvate kinase that converts phosphoenolpyruvate into pyruvate. - Inhibited by ATP and activated by fructose 1,6-bisphosphate 1,3Biphosphoglycerate Regulation by fructose 2,6-bisphosphate Increased glucose= increased fructose 2,6-bisphosphate which stimulates phosphpfructokinase and decreases conc of fructose 6-phohsphate and reduces inhibition by ATP. 3-Phosphoclycerate Glucagon promotes phosphorylation of pyruvate kinase and inhibits when glucose is low as there is no need to produce pyruvate when glucose is low and instead when glucose is high, it can be turned into pyruvate. 2-Phosphoglycerate Water Phosphoenolpyruvate Pyruvate Kinase ATP Made Pyruvate