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# Phenothiazines - **Prochlorperazine, Promethazine & Thiethylperazine** - Phenothiazines are antipsychotics with potent antiemetic property due to $D_2$ antagonism and anti-maucarinic properties. - Sedative property due to anti-histaminic property - Mainly used as anti-emetic in severe...

# Phenothiazines - **Prochlorperazine, Promethazine & Thiethylperazine** - Phenothiazines are antipsychotics with potent antiemetic property due to $D_2$ antagonism and anti-maucarinic properties. - Sedative property due to anti-histaminic property - Mainly used as anti-emetic in severe N&V - Main A/E: EPS, sedation, postural hypotension # Butyrophenones - **Antipsychotic drugs, $D_2$ antagonists** - **Droperidol** - Central $D_2$ antagonist - Main A/E: EPS, postural hypotension - QT prolongation may occur - **Domperidone** - Does not cross BBB. Only blocks $D_2$ in CTZ where BBB is leaky. - May be used in N&V due to Levodopa, without affecting its efficacy. - No EPS. - Used as antiemetic, prokinetic agent & for post partum lactation stimulation.