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Questions and Answers
Droperidol is known for its ability to cross the blood-brain barrier easily.
Droperidol is known for its ability to cross the blood-brain barrier easily.
False (B)
Phenothiazines have a sedative property primarily due to their $D_2$ antagonism.
Phenothiazines have a sedative property primarily due to their $D_2$ antagonism.
False (B)
Domperidone is effective for nausea and vomiting associated with Levodopa while avoiding movement disorders like EPS.
Domperidone is effective for nausea and vomiting associated with Levodopa while avoiding movement disorders like EPS.
True (A)
The main adverse effects associated with Butyrophenones include EPS and QT prolongation.
The main adverse effects associated with Butyrophenones include EPS and QT prolongation.
Prochlorperazine is primarily used for its antidepressant properties.
Prochlorperazine is primarily used for its antidepressant properties.
Phenothiazines are primarily used for their antidepressant properties rather than their antiemetic effects.
Phenothiazines are primarily used for their antidepressant properties rather than their antiemetic effects.
Droperidol has a significant risk of causing extrapyramidal symptoms (EPS) as its main adverse effect.
Droperidol has a significant risk of causing extrapyramidal symptoms (EPS) as its main adverse effect.
Domperidone is effective for treating nausea and vomiting while avoiding extrapyramidal symptoms due to its inability to cross the blood-brain barrier.
Domperidone is effective for treating nausea and vomiting while avoiding extrapyramidal symptoms due to its inability to cross the blood-brain barrier.
The sedative property of phenothiazines is mainly attributed to their $D_2$ antagonism.
The sedative property of phenothiazines is mainly attributed to their $D_2$ antagonism.
Butyrophenones, such as Droperidol, are notable for potentially causing QT prolongation.
Butyrophenones, such as Droperidol, are notable for potentially causing QT prolongation.
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Study Notes
Phenothiazines
- Include Prochlorperazine, Promethazine, and Thiethylperazine as key examples.
- Act as antipsychotics featuring significant antiemetic properties through Dâ‚‚ receptor antagonism and anti-muscarinic effects.
- Exhibit sedative effects attributed to their anti-histaminic action.
- Primarily utilized for severe nausea and vomiting (N&V) relief.
- Common adverse effects (A/E) include extrapyramidal symptoms (EPS), sedation, and postural hypotension.
Butyrophenones
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Comprised of antipsychotic medications that also function as Dâ‚‚ antagonists.
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Droperidol:
- Serves as a central Dâ‚‚ antagonist.
- Notable adverse effects include EPS and postural hypotension.
- Risk of QT interval prolongation.
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Domperidone:
- Does not penetrate the blood-brain barrier (BBB), specifically inhibiting Dâ‚‚ receptors in the chemoreceptor trigger zone (CTZ).
- Can be used for N&V relief associated with Levodopa treatment without diminishing its therapeutic effects.
- Lacks EPS, making it a safer choice for antiemetic purposes.
- Functions as a prokinetic agent and aids in postpartum lactation stimulation.
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