Questions and Answers
Droperidol is known for its ability to cross the blood-brain barrier easily.
False
Phenothiazines have a sedative property primarily due to their $D_2$ antagonism.
False
Domperidone is effective for nausea and vomiting associated with Levodopa while avoiding movement disorders like EPS.
True
The main adverse effects associated with Butyrophenones include EPS and QT prolongation.
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Prochlorperazine is primarily used for its antidepressant properties.
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Phenothiazines are primarily used for their antidepressant properties rather than their antiemetic effects.
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Droperidol has a significant risk of causing extrapyramidal symptoms (EPS) as its main adverse effect.
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Domperidone is effective for treating nausea and vomiting while avoiding extrapyramidal symptoms due to its inability to cross the blood-brain barrier.
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The sedative property of phenothiazines is mainly attributed to their $D_2$ antagonism.
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Butyrophenones, such as Droperidol, are notable for potentially causing QT prolongation.
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Study Notes
Phenothiazines
- Include Prochlorperazine, Promethazine, and Thiethylperazine as key examples.
- Act as antipsychotics featuring significant antiemetic properties through D₂ receptor antagonism and anti-muscarinic effects.
- Exhibit sedative effects attributed to their anti-histaminic action.
- Primarily utilized for severe nausea and vomiting (N&V) relief.
- Common adverse effects (A/E) include extrapyramidal symptoms (EPS), sedation, and postural hypotension.
Butyrophenones
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Comprised of antipsychotic medications that also function as D₂ antagonists.
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Droperidol:
- Serves as a central D₂ antagonist.
- Notable adverse effects include EPS and postural hypotension.
- Risk of QT interval prolongation.
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Domperidone:
- Does not penetrate the blood-brain barrier (BBB), specifically inhibiting D₂ receptors in the chemoreceptor trigger zone (CTZ).
- Can be used for N&V relief associated with Levodopa treatment without diminishing its therapeutic effects.
- Lacks EPS, making it a safer choice for antiemetic purposes.
- Functions as a prokinetic agent and aids in postpartum lactation stimulation.
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Description
This quiz covers key concepts related to antipsychotic drugs, focusing on Phenothiazines and Butyrophenones. Learn about their uses, properties, and side effects, including the important D2 antagonism and antiemetic effects. Challenge your knowledge on these medications to ensure a comprehensive understanding.
