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Major Depressive Disorder (MDD) is one of the most common mental disorders affecting approx. 7.1% of adults in the US Pt.’s with severe depression may experience thoughts of suicide/ psychotic symptoms. If antidepressant therapy is used for major depressive disorder that is mistaken for bipolar depr...

Major Depressive Disorder (MDD) is one of the most common mental disorders affecting approx. 7.1% of adults in the US Pt.’s with severe depression may experience thoughts of suicide/ psychotic symptoms. If antidepressant therapy is used for major depressive disorder that is mistaken for bipolar depression It may precipitate a manic episode/ induce a rapid-cycle bipolar depression & contribute to the incidence of death by suicide in children & adults < 25 yrs of age. Monamine neurotransmitters are norepinephrine, dopamine, & serotonin