Somatosensory Pathways (Pain) - College 4 PDF

Chapter 7 Opener Chapter 7 Somatosensory pathways Table 7.1 Main Long Tracts of the Nervous System Name (and level) of Pathway(s) Function decussation Lateral corti...

Chapter 7 Opener Chapter 7 Somatosensory pathways Table 7.1 Main Long Tracts of the Nervous System Name (and level) of Pathway(s) Function decussation Lateral corticospinal tract Motor Pyramidal decussation (cervicomedullary junction) Posterior column–medial Sensory (vibration, joint Internal arcuate fibers (lower lemniscal pathway position, fine touch) medulla) Anterolateral pathways Sensory (pain, temperature, Anterior commissure (spinal crude touch) cord) Figure 7.1 Posterior Column–Medial Lemniscal Pathway Figure 7.2 Anterolateral Pathways Figure 7.3 Somatotopic Organization of Posterior Column and Anterolateral Pathways in the Spinal Cord Figure 7.4 Spinal Cord Sensory and Motor Spinal Cord Pathways FIGURE 6.3 Basic Spinal Cord Anatomy (Part 2) FIGURE 6.3 Basic Spinal Cord Anatomy Spinothalamic tr. Spinomesenc. To PAG: central modulation of pain Spinoretic to LC/NA. Emotion/arousal aspects of pain(medical help)  Pain Ch. 7 Medical neuroscience & Neuro-anatomy  Examples of type of pain Nociceptive pain: nociceptor is stimulated by a chemical, thermal, or mechanical event that could cause tissue damage Neuropathic pain: Disease or trauma damages the nervous system itself peripheral nervous system: peripheral neuropathic pain central nervous system: central neuropathic pain Due to damage in the brain, brainstem, spinal cord (allodynia)  Tissue damage sensitizes nociceptors (A-Delta and C- fibers)  Epicritic Protopathic Temperature Slow burning aching pain Sense of sharp, pricking, localisable pain S1 S2 PFC Figure 7.2 Anterolateral Pathways Neo Paleo  Epicritic Protopathic Temperature Slow burning aching pain Sense of sharp, pricking, localisable pain S1 S2 PFC Figure 7.2 Anterolateral Pathways Neo Paleo  Paleospinothalamic tract Neospinothalamic tract  Sensori-discriminative aspects Lateral pain system Medial pain system Cogn. evaluat. Medial pain system aspects Motivational-affective aspects  Normal situation ACC Amyg Hippo Sens/discrim Motiv/affect Cogn/evaluat Pain memory Autonomic  Medial pain system Normal situation ACC IL Medial Vcpc Vcpor Amyg Hippo Sens/discrim Motiv/affect Mesencephalon Cogn/evaluat SMT PAG Pain memory Autonomic Reticular formation SRT PBN STT LC Dorsal + ventral horn  Medial pain system Lateral pain system SI SII Normal situation SII ACC PO PO Insula Hypo Insula TMN PVN IL Medial Vcpc Vcpor Amyg Hippo IL Medial Lateral Sens/discrim Motiv/affect Mesencephalon Cogn/evaluat SMT PAG Pain memory Autonomic Reticular formation SRT PBN STT LC STT Dorsal + Dorsal horn ventral horn Figure 7.5 Central Pathways Involved in Pain Modulation Attention! Beethoven 5th Symphony Serenade in G major Waltz of the flowers Herholz et al. Journal of Cognitive Neuroscience, 2012, 24, 1382-1397  Beethoven 5th Symphony Wilkins et al., 2014 PFC  Precuneus PFC DLPFC PAG Higher activity in these areas with more intense physical activity  People with an intellectual disability Nanda de Knegt Vrije Universiteit (Klinische Neuropsychologie)