Booster Cheat Sheets - Biochemistry PDF

Summary

This document presents an overview of biochemistry. It covers various concepts such as biomolecules, types of bonds, and the formation of macromolecules. Suitable for undergraduate students studying this subject.

Full Transcript

© Copyright 2024, Booster Prep Inc. Booster Prep Booster Cheat Sheets – Biochemistry All Rights...

© Copyright 2024, Booster Prep Inc. Booster Prep Booster Cheat Sheets – Biochemistry All Rights Res erved. Biomolecules Atoms & Molecules Types of Molecular Bonds Formation of Macromolecules Atoms: Single unit made up of neutrons, Ionic Bonds: Transfer of e- from one atom to another atom of 1. Dehydration Reaction: Links monomers to form 2. Hydrolysis: Uses water to break polymers into protons, and electrons very different electronegativity polymers, forming H2O in the process monomers Molecule: Groups of 2+ atoms held together Covalent Bonds: Sharing of e- between atoms of similar by chemical bonds due to electron electronegativities interactions Nonpolar: equal e - sharing Macromolecules: Large molecules Polar: unequal e- sharing, forms dipole (polymers) formed from the bonding of Hydrogen Bonds: Weak bond between a hydrogen atom and an smaller molecules (monomers) electronegative atom (F, O, or N) The 4 Types of Organic Macromolecules Proteins Carbohydrates Lipids Nucleic Acids Monomer: Amino acid Monomer: Monosaccharide Nonpolar, hydrophobic molecules Monomer: Nucleotide 1 Amino acids Polymer: Peptide Polymer: Polysaccharide Monomer: Hydrocarbons Polymer: Nucleic acid (DNA, RNA) Linkage type: Peptide bonds Linkage type: Glycosidic Polymer: Hydrocarbon chain Linkage type: Phosphodiester bond Function: Structure, transport, Function: Store energy Linkage type: Covalent carbon-carbon Function: Encode, express, and store genetic info defense, storage, enzymes Function: Insulation, energy storage, Classes of Carbohydrate endocrine signaling, cell structure Structure of DNA/RNA Monosaccharides: Single sugar Types of Lipids Nucleotide: molecule (e.g., Glucose) Structure: Nitrogenous base + 5-C 2 1. Triglycerides: Glycerol + 3 fatty acids Disaccharides: 2 joined sugar sugar + phosphate group Saturated (singl e bonds, straight chain) Alpha helix molecules (e.g., Glucose + DNA: -H attached to 2’ carbon Pleated Unsaturated (double bonds, branched chain) sheet Fructose = Sucrose) 2. Phospholipids: 2 fatty acids + phosphate group of the sugar Polysaccharides: Polymer of RNA: -OH attached to sugar attached to glycerol backbone sugar molecules. Includes starch Are amphipathic with polar head, nonpolar tail. Protein Structures (α-glucose), glycogen (α-glucose), Form phosphol ipid membrane bilay er Nitrogenous Base: cellulose (β-glucose), chitin (β- 3. Steroids: Three 6-membered rings + one 5- DNA: bases are A, T, C, G. Contains deoxyribose sugar and 2 3 1. 1 Primary: Linear chain sequence glucose) membered ring complimentary antiparallel (5’ to 3’) strands of double helix. Pleate d of amino acids E.g., hormones, cholesterol A and T pair via 2 H-bonds 5’ end 3’ end sheet 2. 2 Secondary: Local folding of Porphyrins: 4 joined pyrrole rings with a metal C and G pair via 3 H-bonds chain into α-helices/β-sheets via center atom ↑ GC base pairs = ↑ H-bonds Alpha helix H-bonding between amino & E.g., chlorophyll , hemogl obi n = ↑ temp to split strands carboxyl groups of adjacent Non-lipids, but commonly associated with lipid membranes RNA has bases A, U, C, and G, amino acids with a ribose sugar and is 3 3. Tertiary: 3D shapes due to single stranded noncovalent interactions Chargaff’s Rule: 4 between R groups (disulfide A & T, and G & C are always bonds are covalent exceptions) present in equal amounts 4 4. Quaternary: 3D protein shape (i.e., if DNA is 20% A, consisting of 2+ separate it is also 20% T) 5’ 3’ peptide chains

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