BI214 Lecture 5 PDF

Lecture 5 Even Bloodier! Quiz 1 opens today Closes at 11:00am Monday Exam 1 next Friday (1/31) During class period, on Educat using LockDown Browser TEST THIS AHEAD OF TIME I will provide one sheet of scrap paper if you want it! Computer should be working, connecting to the internet...

Lecture 5 Even Bloodier! Quiz 1 opens today Closes at 11:00am Monday Exam 1 next Friday (1/31) During class period, on Educat using LockDown Browser TEST THIS AHEAD OF TIME I will provide one sheet of scrap paper if you want it! Computer should be working, connecting to the internet, charged, and updated Remember to request DS accommodations at least 5 days ahead! Study guide on Educat Wednesday, 1/29 office hours pushed to 2-3:30pm Tutoring Which physiological changes would you expect to observe in a patient with untreated erythropoietin- secreting tumors? (select all that apply) A) Increased hematocrit B) Decreased red blood cell count C) Elevated blood viscosity D) Increased oxygen carrying capacity E) Lower blood pressure Blood Typing: Blood Typing: Determining Blood Type Agglutination No Agglutination What is my blood type? Blood Typing Practice Matching! A) Type O B) Type A C) Type B D) Type AB Cells of the Buffy Coat Function? Leukocytes = White blood cells (WBCs) 4800-10800 cells/μl blood More? Probably sick Involved in immune function Diapedesis  Diapedesis: WBCs in & out the blood capillaries WBC classes: Granulocytes: ”Grainy” cells Short life span and are produced as needed Agranulocytes: NOT ”grainy” cells Some can live for decades WBC classes Never Let Mom Eat Beans Most to least numerous Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils Cell staining: 2 main histological stains for observing cells/tissues (H&E stain): Hemotoxylin Blue stain when pH > 7 (basic) Nuclei and some storage vesicles Eosin Pink stain when pH < 7 (acidic) Membrane and cytoplasm Granulocytes: Neutrophils Segmented nucleus Kill Bacteria and Fungi Phagocytes Contain granuoles Hydrogen peroxide Lysozymes Neutrophils chase and find foreign stuff Neutrophils are phagocytes Neutrophiles perform NETOSIS (cell death)!!! Granulocytes: Eosinophils Bi-Lobular nucleus Tons of granuoles Spit out Nitric Oxide and cytotoxic enzymes Kills parasitic worms! Eosinophiles love parasitic worms!! Granulocytes: Basophils Very basic Lots of granules Histamine and inflammatory response (antihistamines for allergies) Cancer surveillance Agranulocytes: Monocytes Largest! 2-3 times the size of a RBC Develop into mature macrophages and dendritic cells Huge nucleus, kidney shaped Phagocytic, adaptive immune system activators Agranulocytes: Lymphocytes Size of a RBC Dozens of cells under lymphocyte umbrella Stable and LONG lived Big spherical nucleus Make up adaptive immune system Lymphocytes: T-cell How does the body form WBCs? A. Hematopoiesis B. Erythropoiesis Buffy Coat continued… Buffy coat