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## Satiety ### Hypothalamic centers 1. Satiety center (inhibits appetite) is located in the ventromedial nucleus of the hypothalamus. 2. Feeding center (stimulates appetite) is located in the lateral hypothalamic area of the hypothalamus. ### Anorexigenic neurons Anorexigenic neurons release pr...

## Satiety ### Hypothalamic centers 1. Satiety center (inhibits appetite) is located in the ventromedial nucleus of the hypothalamus. 2. Feeding center (stimulates appetite) is located in the lateral hypothalamic area of the hypothalamus. ### Anorexigenic neurons Anorexigenic neurons release proopiomelanocortin (POMC) in the hypothalamic centers and cause decreased appetite. ### Orexigenic neurons Orexigenic neurons release neuropeptide Y in the hypothalamic centers and stimulate appetite. - Leptin is secreted by fat cells. It stimulates anorexigenic neurons and inhibits orexigenic neurons, thus decreasing appetite. - Insulin and GLP-1 inhibit appetite. - Ghrelin is secreted by gastric cells. It stimulates orexigenic neurons and inhibits anorexigenic neurons, thus increasing appetite. Peptide YY inhibits ghrelin secretion and thus decreases appetite.