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Opioid Analgesic Drugs Overview
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Opioid Analgesic Drugs Overview

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Questions and Answers

Which of the following statements about opioid analgesic drugs is true?

  • They are CNS depressants, potent analgesics for all types of pain except itching, and prolonged use leads to addiction (correct)
  • They are potent analgesics for all types of pain, including itching
  • They are CNS stimulants and cause loss of consciousness
  • Prolonged use does not lead to addiction

    • Which of the following is a natural alkaloid opioid agonist?

  • Methadone
  • Fentanyl
  • Meperidine
  • Morphine (correct)

    • What is the main constituent of the juice derived from the unripe capsule of the opium plant?

  • Fentanyl
  • Morphine (correct)
  • Papaverine
  • Codeine

    • Which of the following is a mixed agonist-antagonist opioid?

    <p>Pentazocine</p> Signup and view all the answers

    What is the bioavailability of morphine when taken orally?

    <p>25%</p> Signup and view all the answers

    Where is morphine conjugated and what is the active form?

    <p>Liver, Morphine-6-Conjugate (active)</p> Signup and view all the answers

    What is the main difference between opioid agonists and mixed agonist-antagonist opioids?

    <p>Opioid agonists are addictive while mixed agonist-antagonists are not.</p> Signup and view all the answers

    Which natural alkaloid is characterized by having negligible CNS action and being spasmolytic on smooth muscles?

    <p>Papaverine</p> Signup and view all the answers

    What is the function of (Morphine - 6- Conjugate) in the body?

    <p>It is the active form of morphine.</p> Signup and view all the answers

    Which opioid agonist is known for its high oral bioavailability and subsequent use via oral administration?

    <p>Codeine</p> Signup and view all the answers

    How is morphine predominantly excreted from the body?

    <p>Unchanged in urine</p> Signup and view all the answers

    Which opioid drug is a synthetic agonist with a higher risk of addiction compared to natural alkaloids?

    <p>Fentanyl</p> Signup and view all the answers

    Which type of opioid agonist is known for being both analgesic and spasmogenic on smooth muscles, as well as causing euphoria?

    <p>Natural Opium alkaloids</p> Signup and view all the answers

    What is the primary reason for the oral bioavailability of morphine being only 25%?

    <p>Poor absorption from the gut</p> Signup and view all the answers

    Which opioid drug is classified as a mixed agonist antagonist opioid?

    <p>Meperidine</p> Signup and view all the answers

    What is a notable characteristic of Papaverine among natural opium alkaloids?

    <p>Negligible CNS action</p> Signup and view all the answers

    In what form is morphine predominantly excreted in the urine?

    <p>Unchanged</p> Signup and view all the answers

    Which synthetic opioid agonist is known to have a higher risk of addiction compared to morphine?

    <p>Methadone</p> Signup and view all the answers

    Which of the following statements about the pharmacokinetics of morphine is incorrect?

    <p>It is primarily excreted unchanged in the urine, with minimal excretion in other bodily fluids.</p> Signup and view all the answers

    Which of the following statements regarding the classification of opioid analgesics is true?

    <p>Butorphanol is a mixed agonist-antagonist opioid, acting as an agonist at mu-opioid receptors and an antagonist at kappa-opioid receptors.</p> Signup and view all the answers

    Which of the following statements about the effects of natural opium alkaloids is incorrect?

    <p>Papaverine acts as a spasmolytic agent on smooth muscles.</p> Signup and view all the answers

    Which of the following statements regarding the effects of opioid analgesic drugs is correct?

    <p>They are potent analgesics for most types of pain, except itching, and prolonged use can lead to addiction.</p> Signup and view all the answers

    Which of the following statements about the excretion of morphine is true?

    <p>Morphine and its active metabolite are excreted in urine, saliva, bile, milk, and gastric fluid.</p> Signup and view all the answers

    Which of the following statements about the pharmacokinetics of morphine is correct?

    <p>Morphine is adequately absorbed from the gut, but has low oral bioavailability due to extensive first-pass metabolism in the liver.</p> Signup and view all the answers

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