Cystic Fibrosis: Aetiology and Genetics

What is the primary cause of cystic fibrosis?

A dysfunction in the CFTR protein (correct)

An autosomal recessive gene

A genetic mutation in the pancreas

A viral infection in the lungs

Which organ system is primarily affected by the thick, sticky secretions in cystic fibrosis?

The cardiovascular system

The respiratory system (correct)

The nervous system

The digestive system

What is the probability that a child will be born with cystic fibrosis if both parents are carriers of the CF gene?

1 in 25

1 in 10

1 in 4 (correct)

1 in 2

What is the primary reason for the impaired mucociliary clearance in the airways of individuals with cystic fibrosis?

Dehydration of the airway surface Signup and view all the answers

What is the current status of a cure for cystic fibrosis?

There is no cure, but treatments are available Signup and view all the answers

What is the approximate percentage of individuals who are carriers of the cystic fibrosis gene?

1 in 25 Signup and view all the answers

Which of the following is NOT a potential complication or co-morbidity associated with cystic fibrosis?

Chronic obstructive pulmonary disease (COPD) Signup and view all the answers

What is the primary method for diagnosing cystic fibrosis in newborns?

Newborn screening followed by a sweat test Signup and view all the answers

Which of the following statements about CFTR modulator therapy is NOT true?

It is a cure for cystic fibrosis Signup and view all the answers

What is the primary reason for the dramatic increase in life expectancy for individuals with cystic fibrosis over the past few decades?

Improved understanding of the disease, screening, and specialist care Signup and view all the answers

Which of the following statements about the diagnosis of cystic fibrosis is true?

It is often suspected based on clinical symptoms alone Signup and view all the answers

Which of the following statements about the impact of cystic fibrosis is NOT true?

It is primarily a disease of the respiratory system Signup and view all the answers