Why is there a leading and lagging strand?
Understand the Problem
The question is asking about the mechanisms of DNA replication, specifically the difference between the leading and lagging strands during this process. The inquiry involves understanding the directionality of DNA synthesis and its implications in replication.
Answer
Due to DNA polymerase's 5' to 3' synthesis direction, creating continuous leading and discontinuous lagging strands.
The leading and lagging strands exist because DNA polymerase can only add nucleotides in the 5' to 3' direction, creating one strand that is synthesized continuously (leading strand) and another that is synthesized in short fragments (lagging strand).
Answer for screen readers
The leading and lagging strands exist because DNA polymerase can only add nucleotides in the 5' to 3' direction, creating one strand that is synthesized continuously (leading strand) and another that is synthesized in short fragments (lagging strand).
More Information
In DNA replication, the lagging strand forms short fragments known as Okazaki fragments, which are later joined together by DNA ligase.
Tips
Common mistakes include confusing which strand is continuous and which is discontinuous. Remember: Leading is continuous, Lagging is discontinuous.
Sources
- Why is there a leading and lagging strand during DNA replication - mytutor.co.uk
- Difference between Lagging and Leading Strand - BYJU'S - byjus.com
- Molecular mechanism of DNA replication (article) | Khan Academy - khanacademy.org
