Which type of mGluR primarily activates Gq signaling?
Understand the Problem
The question is asking which type of metabotropic glutamate receptor (mGluR) primarily activates Gq signaling among the provided options.
Answer
Group I mGluRs (mGluR1 and mGluR5) primarily activate Gq signaling.
Group I mGluRs, including mGluR1 and mGluR5, primarily activate Gq signaling.
Answer for screen readers
Group I mGluRs, including mGluR1 and mGluR5, primarily activate Gq signaling.
More Information
Group I mGluRs, specifically mGluR1 and mGluR5, are coupled to Gq proteins, which activate phospholipase C and lead to the downstream signaling cascade.
Tips
A common mistake is to assume all mGluRs engage in the same signaling pathway. Always identify the specific group subtype (I, II, or III) as they have different signaling partners.
Sources
- Group I Metabotropic Glutamate Receptor Signaling via Gαq/Gα11 - ncbi.nlm.nih.gov
- Metabotropic Glutamate Receptors: Physiology, Pharmacology, and... - pmc.ncbi.nlm.nih.gov
- Metabotropic glutamate receptors (mGluRs) in epileptogenesis - journals.lww.com
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