Which statement accurately describes the regulation of Phosphofructokinase-1 (PFK-1)? A) Inhibited by low AMP levels B) Inhibited by high ADP levels C) Activated by high ATP levels... Which statement accurately describes the regulation of Phosphofructokinase-1 (PFK-1)? A) Inhibited by low AMP levels B) Inhibited by high ADP levels C) Activated by high ATP levels D) Activated by low ATP levels
Understand the Problem
The question is asking for an accurate statement about the regulation of the enzyme Phosphofructokinase-1 (PFK-1), which plays a key role in glycolysis. It involves understanding how various levels of AMP, ADP, and ATP influence the activity of this enzyme.
Answer
Activated by low ATP levels.
The final answer is D) Activated by low ATP levels.
Answer for screen readers
The final answer is D) Activated by low ATP levels.
More Information
Phosphofructokinase-1 (PFK-1) is a key enzyme in glycolysis that is alloelästerically inhibited by high levels of ATP. It is activated when ATP levels are low, indicating a lower energy state in the cell, which stimulates glycolysis to produce more ATP.
Tips
A common mistake is to confuse the role of ATP as both a substrate and regulator, leading to misunderstanding its inhibitory role.
Sources
- Phosphofructokinase 1 - Wikipedia - en.wikipedia.org
- Regulation of cellular respiration - Khan Academy - khanacademy.org
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