Which of these statements about CYP2D6 and antidepressants is true? A) Diminished response to tricyclic antidepressants is expected in PMs B) PMs are less likely to use antidepress... Which of these statements about CYP2D6 and antidepressants is true? A) Diminished response to tricyclic antidepressants is expected in PMs B) PMs are less likely to use antidepressants successfully C) Ultrarapid metabolizers will experience reduced adverse effects D) CYP2D6 does not influence antidepressant efficacy
Understand the Problem
The question is asking for the identification of the true statement regarding the CYP2D6 enzyme and its relation to antidepressant drugs. This involves understanding pharmacogenetics, particularly how variations in the CYP2D6 gene affect the metabolism of certain medications, particularly antidepressants.
Answer
Diminished response to tricyclic antidepressants is expected in PMs.
Diminished response to tricyclic antidepressants is expected in PMs
Answer for screen readers
Diminished response to tricyclic antidepressants is expected in PMs
More Information
Poor metabolizers (PMs) often experience higher plasma concentrations of tricyclic antidepressants due to reduced metabolism, leading to a greater likelihood of side effects and potentially diminished response.
Sources
- CYP2D6 and CYP2C19 genotype‐based dose recommendations - onlinelibrary.wiley.com
- Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype - NCBI - ncbi.nlm.nih.gov
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