Which of the following statements about FceRI is correct? A) It has a low-affinity for IgE. B) Its cross-linking results in mast cell degranulation. C) It is present only on basoph... Which of the following statements about FceRI is correct? A) It has a low-affinity for IgE. B) Its cross-linking results in mast cell degranulation. C) It is present only on basophils. D) It is responsible for T cell activation.
Understand the Problem
The question is asking which statement is correct regarding the FceRI receptor. It involves understanding the characteristics and functions of this receptor in immunology.
Answer
Its cross-linking results in mast cell degranulation.
The correct statement about FcεRI is that its cross-linking results in mast cell degranulation.
Answer for screen readers
The correct statement about FcεRI is that its cross-linking results in mast cell degranulation.
More Information
FcεRI is a high-affinity receptor for IgE, primarily found on mast cells and basophils. It plays a critical role in allergic reactions by triggering degranulation when cross-linked by bound IgE.
Tips
A common mistake is confusing FcεRI with FcεRII, which is the low-affinity IgE receptor.
Sources
- Signalling through the high-affinity IgE receptor FcεRI - Nature - nature.com
- Initial FceRI-mediated signal strength plays a key role in regulating ... - jacionline.org
- Mast cells and basophils in acquired immunity - academic.oup.com
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