Which of the following best describes the role of advanced glycation end-products (AGEs) in periodontal disease related to diabetes? A) AGEs promote capillary growth and vessel pro... Which of the following best describes the role of advanced glycation end-products (AGEs) in periodontal disease related to diabetes? A) AGEs promote capillary growth and vessel proliferation B) AGEs are solely responsible for bacterial infection C) AGEs enhance normal degradation of collagen proteins D) AGEs have no impact on periodontal tissue homeostasis
Understand the Problem
The question is asking to identify the correct statement regarding the role of advanced glycation end-products (AGEs) in the context of periodontal disease associated with diabetes. This involves understanding the biological and pathological implications of AGEs in relation to periodontal health.
Answer
AGEs impact periodontal tissue homeostasis.
AGEs affect periodontal health by altering normal tissue homeostasis, particularly through cross-linking with collagen, impairing its normal degradation and contributing to diseases like periodontitis. Therefore, they impact periodontal tissue homeostasis negatively.
Answer for screen readers
AGEs affect periodontal health by altering normal tissue homeostasis, particularly through cross-linking with collagen, impairing its normal degradation and contributing to diseases like periodontitis. Therefore, they impact periodontal tissue homeostasis negatively.
More Information
AGEs are known to interact with proteins like collagen in the periodontal tissue, leading to the tissue’s stiffening and increased susceptibility to damage, which contributes to poor periodontal health.
Tips
A common mistake is assuming AGEs directly cause bacterial infections; rather, they impair the immune response and tissue integrity.
Sources
- Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis - mdpi.com
- Type 1 Diabetes and Periodontal Health - Clinical Therapeutics - clinicaltherapeutics.com
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