Which molecular feature is specific to class I MHC isotypes?
Understand the Problem
The question is asking which specific molecular feature differentiates class I MHC isotypes from others, and presents four options to choose from based on their characteristics and associations with immune cells.
Answer
α1-α2 domain forming a groove-like structure.
The specific molecular feature of class I MHC isotypes is the presence of the α1-α2 domain forming a groove-like structure for ligand binding.
Answer for screen readers
The specific molecular feature of class I MHC isotypes is the presence of the α1-α2 domain forming a groove-like structure for ligand binding.
More Information
The groove-like structure formed by the α1 and α2 domains of MHC class I molecules is crucial for presenting endogenous antigens to T-cells.
Tips
A common mistake is to confuse MHC class I molecules with class II molecules, which have different structural features and functions.
Sources
- Structural diversity of class I MHC-like molecules and its implications - sciencedirect.com
- MHC class I - Wikipedia - en.wikipedia.org
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