Which is the best method for the synthesis of tert-butyl methyl ether?
Understand the Problem
The question is asking to identify the best method for synthesizing tert-butyl methyl ether from a set of given chemical reactions. The question presents five different chemical reactions and requires knowledge of organic synthesis methods to determine which one is most effective.
Answer
(CH3)3CONa + CH3I
The best method for the synthesis of tert-butyl methyl ether is (CH3)3CONa + CH3I.
Answer for screen readers
The best method for the synthesis of tert-butyl methyl ether is (CH3)3CONa + CH3I.
More Information
Using tert-butoxide ion with iodomethane avoids complications from elimination reactions that can occur with tertiary substrates.
Tips
Avoid using substrates prone to elimination; tertiary halides generally aren't suitable for Sn2 reactions.
Sources
- Preparing Ethers - LibreTexts - chem.libretexts.org
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