Which G protein is associated with the activation of presynaptic M1Rs?
Understand the Problem
The question is asking about the specific G protein that is linked to the activation of presynaptic M1 muscarinic receptors (M1Rs). This requires knowledge of neurobiology and receptor signaling pathways.
Answer
Gαq
The G protein associated with the activation of presynaptic M1Rs is Gαq.
Answer for screen readers
The G protein associated with the activation of presynaptic M1Rs is Gαq.
More Information
The M1 muscarinic acetylcholine receptor (M1R) typically couples to Gαq proteins, leading to increased intracellular calcium and facilitating neurotransmitter release.
Tips
A common mistake is confusing Gαq with other types of G proteins like Gi/o, which are involved with different receptor subtypes or effects.
Sources
- The web page with info on - ScienceDirect - sciencedirect.com
- Structures of the M1 and M2 muscarinic acetylcholine receptor - pmc.ncbi.nlm.nih.gov
- Muscarinic acetylcholine receptor M1 - Wikipedia - en.wikipedia.org
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