Which drug acts mainly by preventing the release of norepinephrine at nerve endings? A) Metyrosine B) Guanethidine C) Bretylium D) Reserpine
Understand the Problem
The question is asking to identify a drug that primarily functions by inhibiting the release of norepinephrine at nerve endings. To solve this, we would need to understand the mechanisms of action of the listed drugs.
Answer
Guanethidine
The drug that acts mainly by preventing the release of norepinephrine at nerve endings is Guanethidine.
Answer for screen readers
The drug that acts mainly by preventing the release of norepinephrine at nerve endings is Guanethidine.
More Information
Guanethidine works by inhibiting the release and/or distribution of norepinephrine from sympathetic nerve endings, which makes it effective in reducing blood pressure.
Tips
A common mistake is confusing the mechanisms of guanethidine and reserpine. Reserpine depletes norepinephrine by binding vesicular monoamine transporters.
Sources
- Guanethidine: Uses, Interactions, Mechanism of Action - DrugBank - go.drugbank.com
- False Neurotransmitter - an overview | ScienceDirect Topics - sciencedirect.com
- Guanethidine | C10H22N4 | CID 3518 - PubChem - pubchem.ncbi.nlm.nih.gov
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