Which class of MHC molecules has a higher range of polymorphism in their binding region?
Understand the Problem
The question is asking about the polymorphism of MHC (Major Histocompatibility Complex) molecules, specifically which class has a higher range of variation in their binding regions. It is focused on comparing different classes and isotypes of MHC molecules.
Answer
MHC class II molecules
MHC class II molecules have a higher range of polymorphism in their binding region.
Answer for screen readers
MHC class II molecules have a higher range of polymorphism in their binding region.
More Information
MHC class II molecules are more promiscuous in peptide binding and have a more open peptide-binding groove, contributing to their higher polymorphism.
Tips
A common mistake is confusing the higher polymorphism specifically in the binding regions of class II molecules with the general polymorphism present in both class I and II molecules.
Sources
- Major Histocompatibility Complex Polymorphism - sciencedirect.com
- The major histocompatibility complex and its functions - ncbi.nlm.nih.gov
- 11.11A: MHC Polymorphism and Antigen Binding - bio.libretexts.org
