Which alleles are identified as significant coding variants of CYP2C9?
Understand the Problem
The question is asking which alleles are considered significant coding variants of the CYP2C9 gene, which is important in pharmacogenetics. It presents multiple-choice options to identify the correct alleles.
Answer
CYP2C9*2 and CYP2C9*3 are significant coding variants of CYP2C9.
The significant coding variants of CYP2C9 include CYP2C92 (R144C) and CYP2C93 (I359L).
Answer for screen readers
The significant coding variants of CYP2C9 include CYP2C92 (R144C) and CYP2C93 (I359L).
More Information
CYP2C92 and CYP2C93 are the most commonly studied and clinically significant variants among the identified alleles of CYP2C9, playing a crucial role in drug metabolism by significantly reducing enzymatic activity compared to the wild-type allele.
Sources
- Pharmacogenomics of CYP2C9: Functional and Clinical Relevance - mdpi.com
- PharmVar GeneFocus: CYP2C9 - PMC - NCBI - ncbi.nlm.nih.gov
- CYP2C9 allelic variants: ethnic distribution and functional significance - sciencedirect.com
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