Which alleles are identified as significant coding variants of CYP2C9?

Understand the Problem

The question is asking which alleles are considered significant coding variants of the CYP2C9 gene, which is important in pharmacogenetics. It presents multiple-choice options to identify the correct alleles.

Answer

CYP2C9*2 and CYP2C9*3 are significant coding variants of CYP2C9.

The significant coding variants of CYP2C9 include CYP2C92 (R144C) and CYP2C93 (I359L).

Answer for screen readers

The significant coding variants of CYP2C9 include CYP2C92 (R144C) and CYP2C93 (I359L).

More Information

CYP2C92 and CYP2C93 are the most commonly studied and clinically significant variants among the identified alleles of CYP2C9, playing a crucial role in drug metabolism by significantly reducing enzymatic activity compared to the wild-type allele.

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