Where are Class III mGluRs predominantly located?
Understand the Problem
The question is asking where Class III metabotropic glutamate receptors (mGluRs) are predominantly located. This requires knowledge about the distribution and function of these receptors in the brain.
Answer
Class III mGluRs are predominantly located in presynaptic terminals.
Class III mGluRs are predominantly located in presynaptic terminals.
Answer for screen readers
Class III mGluRs are predominantly located in presynaptic terminals.
More Information
Group III mGluRs, including mGluR4, mGluR7, and mGluR8, primarily function as modulators of neurotransmitter release by reducing synaptic transmission through their presynaptic location.
Tips
Ensure not to confuse the locations of different mGluR groups, as Group I are primarily postsynaptic, while Group III are presynaptic.
Sources
- Group III metabotropic glutamate receptors and drug addiction - PMC - ncbi.nlm.nih.gov
- Group III metabotropic glutamate receptors gate long-term ... - eLife - elifesciences.org
- Targeting mGluR group III for the treatment of neurodegenerative ... - sciencedirect.com
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