When liver enzymes are induced, which of the following statements are true about drug metabolism? SELECT ALL THAT APPLY A) It may lead to decreased drug effectiveness. B) The dose... When liver enzymes are induced, which of the following statements are true about drug metabolism? SELECT ALL THAT APPLY A) It may lead to decreased drug effectiveness. B) The dose of affected medications may need to be adjusted. C) It can result in increased drug levels in the bloodstream. D) Liver enzyme induction is only relevant for oral medications.
Understand the Problem
The question is asking about the effects of induced liver enzymes on drug metabolism and which statements regarding this phenomenon are true. It requires an understanding of pharmacology and the implications of liver enzyme activity on drug effectiveness and dosing.
Answer
A and B
The final answer is A and B
Answer for screen readers
The final answer is A and B
More Information
Liver enzyme induction can make other drugs metabolize more quickly, often decreasing their effectiveness and necessitating dose adjustments.
Tips
A common mistake is confusing enzyme induction with inhibition, which has opposite effects.
Sources
- Drug Elimination - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Drug Administration - Merck Manual Consumer Version - merckmanuals.com
- Introduction to Pharmacokinetics and Pharmacodynamics - ASHP - ashp.org
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