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What was the best co-solvent for diclofenac in PLO? Also, make a table pointing out the pros and cons for each one tested.

Understand the Problem

The question is asking for information about the effectiveness of different co-solvents for diclofenac in polymer-lipid formulations (PLO), and specifically requests a comparative table outlining the advantages and disadvantages of each co-solvent tested.

Answer

PEG 400 is the best co-solvent for diclofenac in PLO.

The best co-solvent for diclofenac in PLO is PEG 400, which showed the highest solubility.

More Information

PEG 400 and propylene glycol were found to have the highest solubility for diclofenac among the tested solvents, making them suitable choices for the formulation. In contrast, 2-propanol demonstrated the lowest solubility.