What type of transmembrane protein is characteristic of hemidesmosomes and is crucial for their interaction with the basement membrane?
Understand the Problem
The question is asking about the specific type of transmembrane protein that is notable for hemidesmosomes and their connection with the basement membrane. This involves knowledge of cell biology, specifically structures that play a role in cell adhesion.
Answer
α6β4 integrin
The transmembrane protein characteristic of hemidesmosomes that is crucial for their interaction with the basement membrane is α6β4 integrin.
Answer for screen readers
The transmembrane protein characteristic of hemidesmosomes that is crucial for their interaction with the basement membrane is α6β4 integrin.
More Information
Hemidesmosomes are specialized structures that connect epithelial cells to the basement membrane, and integrins like α6β4 play a crucial role in mediating the adhesion between the cells and the matrix, providing stability and facilitating communication.
Tips
Avoid confusing hemidesmosomal integrins with other types of integrins present in different cellular junctions.
Sources
- Molecular architecture and function of the hemidesmosome - PubMed - pubmed.ncbi.nlm.nih.gov
- Structure and Function of Hemidesmosomes: More Than Simple ... - sciencedirect.com
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