What outcome does a Th2-dominated response have in leprosy infections?
Understand the Problem
The question is asking about the effects of a Th2-dominated immune response specifically in the context of leprosy infections. It is looking for the outcome of such a response regarding the severity of the disease, tissue damage, and overall clearance of the infection.
Answer
Th2 response in leprosy leads to lepromatous leprosy, suppressing microbicidal activity and resulting in more extensive disease.
A Th2-dominated response in leprosy infections is associated with the lepromatous form of leprosy, which is characterized by the suppression of microbicidal activity and ineffective control over the bacteria, often leading to more extensive disease. This response is anti-inflammatory and involves cytokines like IL-4, IL-10, and TGF-β.
Answer for screen readers
A Th2-dominated response in leprosy infections is associated with the lepromatous form of leprosy, which is characterized by the suppression of microbicidal activity and ineffective control over the bacteria, often leading to more extensive disease. This response is anti-inflammatory and involves cytokines like IL-4, IL-10, and TGF-β.
More Information
In leprosy infections, a Th2-dominated response fails to control the spread of the bacterial infection effectively as it represents a more humoral and anti-inflammatory response, which typically does not mount a vigorous attack against the bacteria.
Tips
A common mistake is to confuse the Th2 response with Th1. Th1 is more effective in bacterial infections like leprosy due to its cell-mediated nature, while Th2 is more humoral.
Sources
- Leprosy As a Complex Infection: Breakdown of the Th1 and Th2 - researchgate.net
- Transcription factors STAT-4, STAT-6 and CREB regulate Th1/Th2 - pmc.ncbi.nlm.nih.gov
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