What key function does PLP perform aside from its role in transamination?
Understand the Problem
The question is asking about the key functions of PLP (pyridoxal phosphate) beyond its involvement in transamination. We need to identify which of the listed options accurately reflects an important role of PLP.
Answer
PLP acts as an 'electron sink', participating in reactions like decarboxylation and deamination.
Aside from its role in transamination, PLP acts as an 'electron sink', helping to stabilize negative charges on reaction intermediates. It also participates in various reactions like decarboxylation, deamination, and plays a role in neurotransmitter metabolism.
Answer for screen readers
Aside from its role in transamination, PLP acts as an 'electron sink', helping to stabilize negative charges on reaction intermediates. It also participates in various reactions like decarboxylation, deamination, and plays a role in neurotransmitter metabolism.
More Information
PLP is essential in facilitating enzyme processes by stabilizing reaction intermediates in amino acid metabolism and other pathways.
Tips
A common mistake is assuming PLP’s role is limited to amino acid metabolism, ignoring its broader participation in multiple biochemical pathways.
Sources
- 17.2: Pyridoxal Phosphate (Vitamin B6) - Chemistry LibreTexts - chem.libretexts.org
- Catalytic Roles of Coenzyme Pyridoxal-5′-phosphate (PLP ... - NCBI - ncbi.nlm.nih.gov
- Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of ... - ncbi.nlm.nih.gov
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