What is the role of ribonucleotide reductase in deoxyribonucleotide synthesis and how is enzyme regeneration achieved?
Understand the Problem
The text discusses deoxyribonucleotide synthesis, focusing on the role of ribonucleotide reductase in DNA synthesis and the regeneration of enzymes involved in the process.
Answer
RNR converts ribonucleotides to deoxyribonucleotides; regeneration via thioredoxin and thioredoxin reductase.
Ribonucleotide reductase catalyzes the conversion of ribonucleotides to deoxyribonucleotides, essential for DNA synthesis. Enzyme regeneration is achieved through thioredoxin, which donates hydrogen atoms, and is itself regenerated by thioredoxin reductase using NADPH.
Answer for screen readers
Ribonucleotide reductase catalyzes the conversion of ribonucleotides to deoxyribonucleotides, essential for DNA synthesis. Enzyme regeneration is achieved through thioredoxin, which donates hydrogen atoms, and is itself regenerated by thioredoxin reductase using NADPH.
More Information
Ribonucleotide reductase is essential for DNA synthesis and repair as it provides the deoxyribonucleotide precursors necessary for these processes. Its proper function and regeneration are critical for cell division and genome maintenance.
Tips
A common mistake is not considering the role of thioredoxin in the regeneration process, which is essential for the continued activity of ribonucleotide reductase.
Sources
- Structure, function, and mechanism of ribonucleotide reductases - pubmed.ncbi.nlm.nih.gov
- Ribonucleotide Reductase - an overview | ScienceDirect Topics - sciencedirect.com
- Ribonucleotide reductase - Wikipedia - en.wikipedia.org
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