What is the role of phospholipase C in the signaling of hydrophilic hormones?
Understand the Problem
The question is asking about the specific function of phospholipase C within the context of hydrophilic hormone signaling. The role of phospholipase C is to cleave a specific phospholipid which is a part of the signaling pathway.
Answer
Phospholipase C breaks down PIP2 to produce IP3 and DAG, which are crucial for intracellular signaling.
The role of phospholipase C in the signaling of hydrophilic hormones is to catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) in cell membranes, producing inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 increases intracellular calcium levels, while DAG activates protein kinase C, both critical for signal transduction.
Answer for screen readers
The role of phospholipase C in the signaling of hydrophilic hormones is to catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) in cell membranes, producing inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 increases intracellular calcium levels, while DAG activates protein kinase C, both critical for signal transduction.
More Information
The PIP2 breakdown by phospholipase C is a key step in cellular responses to hormones that cannot pass through the cell membrane due to their hydrophilic nature. This process is vital for numerous physiological processes, including calcium signaling and the activation of protein kinase pathways.
Tips
A common mistake is to confuse the roles of IP3 and DAG. Remember that IP3 primarily increases calcium levels, and DAG activates protein kinase C.
Sources
- Phospholipase C Pathway | Cell Signaling Technology - cellsignal.com
- Hormones | Anatomy and Physiology II - Lumen - courses.lumenlearning.com
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